An interventional study of Transcutaneous Auricular Point Electrical Stimulation and micro-stimulation in Tic Disorder, sponsored by The First Affiliated Hospital of Zhejiang Chinese Medical University. Not yet recruiting at 1 site in China. Open to participants aged 6 Years to 18 Years. Per ClinicalTrials.gov, last updated 2026-10-02.
Sponsored by The First Affiliated Hospital of Zhejiang Chinese Medical University · Not applicable, Interventional, and Treatment
The objective of this trial is to evaluate the effect of transcutaneous auricular point electrical stimulation compared to the micro-stimulation in the treatment of chronic tic disorder in adolescents
Participants will be randomly assigned to receive transcutaneous auricular point electrical stimulation or micro-stimulation treatment. Both treatments will be administered 5 times per week, starting from the time of enrollment and lasting for 8 weeks. The study outcomes will be evaluated at four time points: baseline (Week 0), during treatment (Week 4), and after treatment (Week 8), with a follow-up period of 4 weeks after the end of treatment (Week 12).
98 studies on the registry are indexed under Tic Disorders; 23 are open to participants now.
This study's planned enrollment of 124 is above the median of 50 across 80 interventional studies indexed under Tic Disorders.
Browse Tic Disorders studies →The First Affiliated Hospital of Zhejiang Chinese Medical University is the lead sponsor of 37 studies on the registry; 18 are open to participants now.
Counted across the registry records on this site, refreshed daily.
（1）Meet DSM-5 diagnostic criteria for Tourette syndrome or persistent (chronic) motor or vocal tic disorder; (2) Age between 6 and 18 years, regardless of gender; (3) YGTSS-TTS score >15; for participants with only motor or vocal tics, a YGTSS-TTS score >10 is required; (4) If currently on medication, the dosage of tic-related medications must have been stable for the past 4 weeks, and no changes to medication are planned during the study period; (5) No physical therapy or surgical treatment for this condition within the past 8 weeks; (6) The participant's guardian signs an informed consent form, and participants aged 8 years and older sign an appropriate assent document, voluntarily agreeing to participate in the study.
Exclusion Criteria:
(1) Presence of severe mental disorders, such as schizophrenia, bipolar disorder, severe depression, suicide risk, etc., or severe cognitive dysfunction, making it impossible to cooperate with the study; (2) Skin damage, infection, eczema, etc. in the ear area, making treatment impossible; (3) Implanted with cardiac pacemaker, implantable nerve stimulator or other electronic implant devices; (4) Complicated with severe cardiovascular or other important organ diseases; (5) Currently participating in other clinical studies.
After skin disinfection, the connecting clip is fixed to the Auricular Point, an electroacupuncture apparatus will be connected. The stimulation parameters will be sparse and dense waves, 4/20Hz (4Hz for 5 seconds, 20Hz for 10 seconds, alternating); the pulse width is 0.2ms ± 30%, and the current intensity will be adjusted according to the participant's comfort level.
Device: Transcutaneous Auricular Point Electrical Stimulation · Device: micro-stimulation
After skin disinfection, the connecting clip is fixed to the Auricular Point, an electroacupuncture apparatus will be connected. The stimulation parameters will be sparse and dense waves, 4/20Hz (4Hz for 5 seconds, 20Hz for 10 seconds, alternating); the pulse width is 0.2ms ± 30%, and the current intensity will be adjusted according to the participant's comfort level.
Device: Transcutaneous Auricular Point Electrical Stimulation · Device: micro-stimulation
Participants in the Transcutaneous Auricular Point Electrical Stimulation group will receive Transcutaneous Auricular Point Electrical Stimulation 5 a week, with each session lasting 30 minutes. The treatment will start from the time of enrollment and lasting for 8 weeks.
Participants in the Transcutaneous Auricular Point Electrical Stimulation group will receive Transcutaneous Auricular Point Electrical Stimulation 5 a week, with each session lasting 30 minutes. The treatment will start from the time of enrollment and lasting for 8 weeks.
Yale Global Tic Severity Scale Total Tic Score
Time frame: baseline (Week 0), during treatment (Week 4), and after treatment (Week 8), with a follow-up period of 4 weeks after the end of treatment (Week 12)
Change in YGTSS-TTS score from baseline
Time frame: week 4,week12
Change in YGTSS scores across other dimensions relative to baseline
Time frame: week 4,week 8,week 12
Children's Yale-Brown Obsessive Compulsive Scale
Time frame: Week 0, Week 4, Week 8, Week 12
Swanson, Nolan, and Pelham-IV-18
Time frame: Week 0, Week 4, Week 8, Week 12
Child and Adolescent Gilles de la Tourette Syndrome-Quality of Life
Time frame: Week 0, Week 4, Week 8, Week 12
Plan to share: Undecided
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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The First Affiliated Hospital of Zhejiang Chinese Medical University