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CompletedNCT07347327Updated Jan 22, 2026

The Effect of Dual-target tACS Combined With Speech Training on Repetition Disorder After Stroke

An interventional study of speech training and real tACS in Aphasia, sponsored by Ke Dong, MD. Completed at 1 site in China. Open to participants aged 30 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-01-22.

Sponsored by Ke Dong, MD · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 3 years after the study started (first participant enrolled Jan 2023, registered Jan 2026).
Phase
Not applicable
Study type
Interventional
Enrollment
28
Allocation
Randomized
Ages
30 Years to 80 Years
Sex
All
01

Study summary

This clinical trial aims to study whether dual-target transcranial alternating current stimulation (tACS) applied to the auditory and motor brain region can improve repetition disorder in people with stroke, and to evaluate the safety of tACS. The main goals are to answer the following questions:

  1. Can dual-tACS stimulation of the auditory and motor brain area improve repetition functions in people with aphasia after stroke?
  2. Can it improve the integration of auditory information and speech motor control during communication?

Researchers will compare the effects of real tACS versus sham (placebo) stimulation to see if real stimulation leads to better outcomes in aphasia patients.

Participants will:

  1. Receive one extra 20-minute session of either real or sham tACS each day for 10 days
  2. Attend clinic visits before and after 10-days stimulation for clinical assessments(WAB) and fNIRS recording related brain activity
02

Conditions studied

  • Aphasia

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03

In context

Aphasia

365 studies on the registry are indexed under Aphasia; 89 are open to participants now.

This study's enrollment of 28 is close to the median of 30 across 316 interventional studies indexed under Aphasia.

Browse Aphasia studies →

Lead sponsor

Ke Dong, MD is the lead sponsor of 6 studies on the registry; 4 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
30 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Meeting the diagnostic criteria for hemorrhagic or ischemic stroke in the Chinese Guidelines for the Prevention and Treatment of Cerebrovascular Diseases(2nd edition), with the first onset, single hemisphere stroke, and confirmed by CT or MRI,course of diease 1-6 months;
  • Age ranging from 30 to 80 years old;
  • Native language is Mandarin or Cantonese;
  • Right-handed;
  • Diagnosed with aphasia by the Western Aphasia Battery (WAB) scale;
  • Able to cooperate in completing the speech repetition test;
  • Normal hearing.

Exclusion criteria

Exclusion Criteria:

  • Currently receiving non-invasive brain stimulation treatment;
  • Lesions involving the Broca or STG brain regions;
  • History of epilepsy, mental illness,or other neurological or mental disorders;
  • Any contraindications for transcranial electrical stimulation.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Investigator, Outcomes assessor)
Enrollment
28 participants (actual)

Study arms

  • Experimental
    real group

    dual-target tACS on auditory and motor brain area at a frequency of 8 Hz,with individualized current intensity, delivered for 20 minutes.

    Behavioral: speech training · Other: real tACS

  • Sham comparator
    sham group

    sham tACS except for turning down the current intensity to zero during the 20-minute period, all other parameters are identical to those in real group.

    Behavioral: speech training · Other: sham tACS

Interventions

  • Behavioralspeech training

    speech training(especially repetition training) synchronized with tACS stimulation

  • Otherreal tACS

    dual-target tACS on auditory and motor brain area at a frequency of 8 Hz,with individualized current intensity, delivered for 20 minutes.

  • Othersham tACS

    except for turning down the current intensity to zero during the 20-minute period, all other parameters are identical to those in real group.

06

What researchers measure

Primary outcomes

  1. Western Aphasia Battery (WAB) score

    Western Aphasia Battery (WAB) score：0-100，higher score means better language function

    Time frame: Baseline and 10-days

07

Study locations

1 site
  • Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University
    Guangzhou, Guangdong, China
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 22, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07347327
Lead sponsor
Ke Dong, MD
Responsible party
Ke Dong, MD (Principal Investigator, First Affiliated Hospital, Sun Yat-Sen University) — Sponsor-investigator
First posted
Jan 16, 2026
Start date
Jan 1, 2023
Primary completion
Dec 26, 2025
Completion
Dec 29, 2025
Last update
Jan 22, 2026

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.

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