ClinicalTrials.gg
CompletedNCT07308743Updated Oct 22, 2026

Impact of Computer-aided Detection System on the Right Colon Adenoma Miss Rate

An interventional study of Computer-aided detection-assisted colonoscopy and Conventional white-light colonoscopy in Colon Adenomas, Colon Polyps and Sessile Serrated Lesion, sponsored by Nanfang Hospital, Southern Medical University. Completed at 1 site in China. Open to participants aged 40 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-22.

Sponsored by Nanfang Hospital, Southern Medical University · Not applicable, Interventional, and Diagnostic

Updated Oct 22, 2026Now CompletedPrimary completion moved+4 moreGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
686
Allocation
Randomized
Ages
40 Years to 75 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 41 studies in Colonic Polyps with a site in China — 7 open to participants now, 8 under way, none of them phase 3. Colonic Polyps · China.

Enrollment
13th of 35
686 · median 352
Started
2025
with 4 others
No phase
32 of 41
6 open now
Registered
40th of 41
by date

Among the 41 studies in Colonic Polyps with a site in China, this one is the 13th largest by enrollment of the 35 interventional ones that give a count, is one of 5 that started in 2025, is one of 32 with no phase, and was the 40th registered.

Colonic Polyps

377 studies on the registry are indexed under Colonic Polyps; 57 are open to participants now.

Browse Colonic Polyps studies →

Open to participants now

7 of the 41 studies in Colonic Polyps with a site in China are open now. Recruiting first, the newest first:

2 more — sign in →

All 7 open studies →

A study can be open while its sites in China have not opened yet or have stopped. Only those recruiting at a site in China →

Who these studies take

Of the 39 Colonic Polyps studies recruiting now, 23 (59%) set no upper age limit and 4 (10%) stop at 75 or younger; 3 take children under 18; 11 take healthy volunteers.

This study: 40 Years to 75 Years · all sexes · healthy volunteers too.

The full table on the hub →

This tab as a report to print or save as PDF → With an account.

Was this useful?
Watch this landscapeDownload CSVNarrow it in search →With an account: a weekly mail of what changed among 41 studies in Colonic Polyps with a site in China, or all of them as a file.
02

Study summary

This is a prospective, multicenter randomized controlled trial designed to determine whether the use of computer-aided detection system could reduce the miss rates of adenomas, SSLs, and polyps in the proximal colon during tandem colonoscopy.

Read the detailed description

This is a prospective, multicenter, tandem randomized controlled trial conducted at 8 endoscopy centers in China (Guangdong). Participants are randomized at a 1:1 ratio to undergo either CADe-assisted colonoscopy first or conventional white-light colonoscopy first. The second colonoscopy is performed immediately afterward in tandem fashion by the same endoscopist.

A variable-block randomization design with block sizes ranging from 4 to 6 was adopted. The random sequence was generated in advance by the lead center using a digital random number generator to allocate participants to study groups. After successful cecal intubation and confirmation of adequate right sided bowel cleaning, the performing operator was informed of the group allocation by the trained research assistants. All participants, pathologists, and statisticians remained blinded to group allocation throughout the study.

03

Conditions studied

  • Colon Adenomas
  • Colon Polyps
  • Sessile Serrated Lesion

Browse trials for

Keywords

  • computer-aided detection
  • proximal adenoma miss rate
  • Randomized Tandem Colonoscopy Study
04

Who can participate

Ages eligible
40 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Patients age 40-75 years old, regardless of gender
  2. Patients presenting for physical examination, colorectal cancer screening or diagnosis
  3. Patients voluntarily signs an form

Exclusion criteria

Exclusion Criteria:

  1. Unable to cooperate ot tolerate colonoscopy
  2. History of inflammatory bowel disease
  3. History of colorectal cancer
  4. Previous colorectal surgery
  5. History of recurrent constipation
  6. Taking anticoagulant and antiplatelet drugs berfore procedure
  7. High risk conditions such as severe cardiovascular and cerebrovascular diseases, severe anemia, or uncorrected infections
  8. Pregnant or lactating women Researchers concluded that patient was not suitable to participate in this trial.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
686 participants (actual)

Study arms

  • Experimental
    Computer-aided detection-assisted colonoscopy

    Tandem colonoscopy of proximal colon assisted with computer-aided detection system followed by conventional white-light colonoscopy

    Device: Computer-aided detection-assisted colonoscopy

  • Active comparator
    Conventional white-light colonoscopy

    Tandem conventional white-light colonoscopy of proximal colon followed by usual computer-aided detection-assisted colonoscopy

    Procedure: Conventional white-light colonoscopy

Interventions

  • DeviceComputer-aided detection-assisted colonoscopy

    Computer-aided detection-assisted colonoscopy for detection of colonic polyp

  • ProcedureConventional white-light colonoscopy

    Conventional white-light colonoscopy

06

What researchers measure

Primary outcomes

  1. Right adenoma missed rate

    The number of adenomas identified during the second right colon inspection divided by the overall number of adenomas identified during the first and second right colon inspection.

    Time frame: At the time of index tandem colonoscopy

Secondary outcomes

  1. Right polyp missed rate

    The number of polyps identified during the second right colon inspection divided by the overall number of polyps identified during the first and second right colon inspection.

    Time frame: At the time of index tandem colonoscopy

  2. Right serrated polyp missed rate

    The number of serrated polyp identified during the second right colon inspection divided by the overall number of serrated polyp identified during the first and second right colon inspection.

    Time frame: At the time of index tandem colonoscopy

  3. Right SSLs missed rate

    The number of SSLs identified during the second right colon inspection divided by the overall number of SSLs identified during the first and second right colon inspection.

    Time frame: At the time of index tandem colonoscopy

  4. Right advanced adenoma missed rate

    The number of advanced adenomas identified during the second right colon inspection divided by the overall number of advanced adenomas identified during the first and second right colon inspection.

    Time frame: At the time of index tandem colonoscopy

07

Study locations

1 site
  • Nanfang Hospital, Southern Medical University
    Guangzhou, Guangdong 510515, China
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedDate before it movedWhere the date was before it movedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Dec 2025 to primary completion in May 2026, 4 months.

Of 132 non-industry interventional studies with no phase under Colonic Polyps, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 35. This study's 4 months is below that.

Counting every sponsor, half of 149 studies reached it within 17 months; a quarter within 9 and three quarters within 35.

Since we started tracking on Sep 25, 2026, the dates moved once, on Oct 22, 2026: primary completion May 2027 → May 2026 and completion Jul 2027 → May 2026.

Earlier changes are on the record history on ClinicalTrials.gov ↗

How these figures are worked out, and which studies are left out of them.

Registered
Dec 17, 2025
First posted
Dec 30, 2025
StartActual
Dec 25, 2025
Primary completionActual
May 5, 2026was May 2027
CompletionActual
May 12, 2026was Jul 2027
Last update
Oct 22, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Status
Not yet recruiting→Completed
changed Oct 22, 2026
Primary completion
May 2027→May 5, 2026 (actual)
Oct 22, 2026
Study completion
Jul 2027→May 12, 2026 (actual)
Oct 22, 2026
Primary outcomes
1 edited
What changed in the outcomes
  • EditedProximalRight adenoma missed rateTime frame: One day → At the time of index tandem colonoscopy
Oct 22, 2026
Secondary outcomes
3 edited, 1 added
What changed in the outcomes
  • EditedProximalRight polyp missed rateTime frame: One day → At the time of index tandem colonoscopy
  • EditedProximalRight SSLs missed rateTime frame: One days → At the time of index tandem colonoscopy
  • EditedProximalRight advanced adenoma missed rateTime frame: One day → At the time of index tandem colonoscopy
  • AddedRight serrated polyp missed rateTime frame: At the time of index tandem colonoscopy
Oct 22, 2026
Title
Impact of Computer-aided Detection System on the ProximalRight Colon Adenoma Miss Rate
Oct 22, 2026
Show all 1 update
  1. Oct 22, 2026
    Not yet recruiting→Completed
    Primary completion May 2027→May 5, 2026 (now actual)
    Study completion Jul 2027→May 12, 2026 (now actual)
    Primary outcomes 1 edited
    What changed in the outcomes
    • EditedProximalRight adenoma missed rateTime frame: One day → At the time of index tandem colonoscopy
    Secondary outcomes 3 edited, 1 added
    What changed in the outcomes
    • EditedProximalRight polyp missed rateTime frame: One day → At the time of index tandem colonoscopy
    • EditedProximalRight SSLs missed rateTime frame: One days → At the time of index tandem colonoscopy
    • EditedProximalRight advanced adenoma missed rateTime frame: One day → At the time of index tandem colonoscopy
    • AddedRight serrated polyp missed rateTime frame: At the time of index tandem colonoscopy
    Title Impact of Computer-aided Detection System on the ProximalRight Colon Adenoma Miss Rate
    + 3 other changes: verification date, description and contact details

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07308743
Collaborators
The Fifth Affiliated Hospital of Zunyi Medical College, Longgang District People's Hospital of Shenzhen, Yangjiang People's Hospital, Jiangmen Central Hospital, Dongguan Shuixiang Central Hospital, Pingshan District People's Hospital of shenzhen, The Third People's Hospital of Huizhou
Responsible party
Sponsor
First posted
Dec 30, 2025
Start date
Dec 25, 2025
Primary completion
May 5, 2026
Completion
May 12, 2026
Last update
Oct 22, 2026

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion