An interventional study of Cold Snare Piecemeal Resection (CSPR) and Cold Snare Endoscopic Mucosal Resection (Cold EMR) in Colon Polyp, Colon Adenoma and Serrated Polyp, sponsored by Indiana University. Enrolling by invitation at 9 sites in 2 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-21.
Sponsored by Indiana University · Not applicable, Interventional, and Prevention
The study will compare the use of cold snare piecemeal resection (CSPR) vs cold endoscopic mucosal resection (Cold EMR). The study will include two cohorts: one cohort for conventional adenomas 10-19mm in size and one cohort for serrated lesions 10mm or larger.
377 studies on the registry are indexed under Colonic Polyps; 57 are open to participants now.
This study's planned enrollment of 570 is above the median of 274 across 250 interventional studies indexed under Colonic Polyps.
Browse Colonic Polyps studies →Indiana University is the lead sponsor of 986 studies on the registry; 198 are open to participants now.
Of its 148 completed or terminated interventional studies of FDA-regulated products, 118 (80%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Found to have:
Exclusion Criteria:
Polyps confirmed to be anything other than:
Patients with a known or suspected diagnosis of any of the following polyposis syndromes with known genetic mutations:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Conventional adenomas sized 10-19mm or serrated lesions 10mm or larger found during colonoscopy will be removed using CSPR technique.
Procedure: Cold Snare Piecemeal Resection (CSPR)
Conventional adenomas sized 10-19mm or serrated lesions 10mm or larger found during colonoscopy will be removed using Cold EMR technique.
Procedure: Cold Snare Endoscopic Mucosal Resection (Cold EMR)
Qualifying polyps randomized to Cold Snare Piecemeal Resection (CSPR) will be removed using cold snare techniques (no electrocautery, no submucosal injection.)
Qualifying polyps randomized to Cold Snare Endoscopic Mucosal Resection (Cold EMR) will be removed using cold snare techniques (no electrocautery, with submucosal injection.)
Efficacy of Resection (Central Post-Resection Biopsies)
Efficacy of resection will be assessed by biopsies in four or six quadrants of the perimeter of the defect post-resection and two biopsies from the center of the defect post-resection. Comparison of the biopsy pathology results for polyps removed by Cold EMR vs CSPR.
Time frame: 1 day
Efficacy of Resection (Peripheral Post-Resection Biopsies)
Efficacy of resection will be assessed by biopsies in four or six quadrants of the perimeter of the defect post-resection and two biopsies from the center of the defect post-resection. Comparison of the biopsy pathology results for polyps removed by Cold EMR vs CSPR.
Time frame: 1 day
Polyp Resection Time
The time it takes to remove the polyp completely
Time frame: 1 day
Resection Preparation Time
The time it takes to prepare for polyp removal
Time frame: 1 day
Total Procedure Time
The total time it takes to complete the colonoscopy procedure
Time frame: 1 day
Adverse Events
The number of complications for each randomization arm during and after the procedure
Time frame: 30 Days
Rate of Recurrence at First Surveillance Colonoscopy for Polyps ≥ 20mm
The recurrence rate of serrated lesions ≥ 20mm measured at the first follow-up colonoscopy
Time frame: At first surveillance colonoscopy, typically 6 months to 12 months
Plan to share: No — De-identified data may be shared in the future upon request per PI discretion.
Started Sep 2024 (actual). Primary completion is estimated for Jul 2027, 34 months after the start.
Of 132 non-industry interventional studies with no phase under Colonic Polyps, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 35. This study's planned 34 months is above that.
Counting every sponsor, half of 149 studies reached it within 17 months; a quarter within 9 and three quarters within 35.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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