An interventional study of Lung MRI Protocol with Functional and Contrast-Enhanced Sequences in Interstitial Lung Diseases (ILD), sponsored by University Hospital Heidelberg. Recruiting at 2 sites in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-12-24.
Sponsored by University Hospital Heidelberg · Not applicable, Interventional, and Diagnostic
The main objective of this study is to investigate the utility of functional MRI to differentiate, characterize, and monitor subgroups of ILD. This can be broken down into three specific objectives:
Determine if ILD features observed on high-resolution computed tomography (HRCT), such as ground glass opacities (GGO), are functionally different.
Analyse MRI metrics within each subgroup to determine whether these metrics distinguish different ILDs.
Assess MRI metrics longitudinally to see if these parameters change with disease progression, stability, or reversibility.
646 studies on the registry are indexed under Lung Diseases, Interstitial; 237 are open to participants now.
This study's planned enrollment of 200 is above the median of 54 across 355 interventional studies indexed under Lung Diseases, Interstitial.
Browse Lung Diseases, Interstitial studies →University Hospital Heidelberg is the lead sponsor of 175 studies on the registry; 48 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Diagnostic Test: Lung MRI Protocol with Functional and Contrast-Enhanced Sequences
Participants will undergo a lung MRI protocol consisting of structural imaging, non-contrast functional imaging, and contrast-enhanced imaging. Some sequences are custom-developed and performed during free breathing to accommodate patients with respiratory limitations.
Identification of ILD Subtypes Using Baseline MRI Metrics
Assess whether baseline MRI metrics can accurately differentiate subtypes of interstitial lung disease, using clinician diagnosis (based on multidisciplinary discussion) as the reference standard.
Time frame: Baseline (first MRI scan)
Correlation of Longitudinal MRI Changes with Disease Progression
Evaluate changes in MRI metrics over time and their correlation with ILD progression, using ATS/ERS/JRS/ALAT criteria.
Time frame: From enrollment (baseline MRI) through up to 1-year after enrollment; follow-up assessments will only be performed if clinically indicated.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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University Hospital Heidelberg