An Early Phase 1 interventional study of local antibiotic application of topical minocycline and Scaling and Root Planing in Periodontitis, Diabetes Mellitus Type 2, sponsored by Case Western Reserve University. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-19.
Sponsored by Case Western Reserve University · Early Phase 1, Interventional, and Treatment
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Among 75 studies in Periodontitis with a site in United States — 13 open to participants now, 16 under way, none of them phase 3. Periodontitis · United States.
Among the 75 studies in Periodontitis with a site in United States, this one is the 39th largest by planned enrollment of the 56 interventional ones that give a count, is one of 4 that started in 2026, is one of 5 in phase 1, reaches primary completion later than 11 of the 14 other live ones, and was the 72nd registered.
1,235 studies on the registry are indexed under Periodontitis; 298 are open to participants now.
Browse Periodontitis studies →13 of the 75 studies in Periodontitis with a site in United States are open now. Recruiting first, the newest first:
McGuire Institute · Sites in United States
Ages 30–75
University of Minnesota · Sites in United States
Ages 18+ · Healthy volunteers
Erchonia Corporation · Sites in United States
Ages 22–75
Missouri Department of Health and Senior Services · Sites in United States
Ages 60–100 · Healthy volunteers
Texas A&M University · Sites in United States
Ages 30–75 · Healthy volunteers
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 160 Periodontitis studies recruiting now, 79 (49%) set no upper age limit and 60 (38%) stop at 75 or younger; 12 take children under 18; 77 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
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75 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 7 · Phase 2 9 · Phase 3 7 · Phase 4 2
First in 1999; this study’s year is marked. 4 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 42 is close to the median of 44 across 848 interventional studies indexed under Periodontitis.
Median enrollment 58 across the 56 interventional studies, 105 across the 18 observational. Of the 56 that completed or were terminated, 14 (25%) have results posted.
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16 of 75 have an industry lead sponsor. The 10 most frequent:
Case Western Reserve University is the lead sponsor of 160 studies on the registry; 28 are open to participants now.
Of its 10 completed or terminated interventional studies of FDA-regulated products, 7 (70%) have results posted.
Case Western Reserve University has 1 study filed under Periodontitis — fewer than ten, so there is no comparison to draw.
6 of the studies in Periodontitis with a site in United States that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07610902Louisiana State University Health Sciences Center in New OrleansPeriodontal Inflammation and Epigenetics in Obese Individuals | 2026-12-30 |
| NCT06914596McGuire InstituteA Clinical Trial Comparing 2x/Day for 30-minutes Use of the Emanate Perio PODS Post-SRP to a Control Group Post-SRP. | 2026-12-30 |
| NCT04805320University of NebraskaAssociation of Periodontal Inflammation on Immune Response in Wound Healing | 2027-01 |
| NCT06948162University of MinnesotaExploration of the Utility of Dental-dedicated MRI for Dentistry | 2027-03-31 |
| NCT07298057Case Western Reserve UniversityEffect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics | 2027-06 |
Add all 6 to your calendar (.ics) → With an account.
Among the 75 studies in Periodontitis with a site in United States, from their registry updates:
This tab as a report to print or save as PDF → With an account.
Periodontitis is a prevalent chronic inflammatory disease that exacerbates systemic inflammation and poses challenges for glycemic control in diabetic patients. While scaling and root planing (SRP) remains the cornerstone of periodontal therapy, adjunctive treatments such as Arestin (minocycline microspheres) have shown promise in enhancing clinical outcomes. This study aims to evaluate the impact of adding Arestin to SRP on periodontal pocket closure, glycemic control, and systemic inflammation in diabetic patients with periodontitis.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
HbA1c
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Minocycline microspheres (Arestin®) / (4 mg per cartridge) prefilled delivery syringe / Arestin will be placed in the pocket only one time after scaling and root planing.
Drug: local antibiotic application of topical minocycline
Scaling and Root Planing Alone
Procedure: Scaling and Root Planing
Scaling and Root planing + local application of Arestin ( Minocycline microsphere)
Also known as: Arestin Minocicline microsphere
Only scaling and root planing
Pocket Closure
Pocket Depth (PD ≤4 mm)
Time frame: Baseline, 3 Months, 6 Months
Changes in Glycemic Control (HbA1c)
Changes in Blood Sugar Level
Time frame: Baseline, 3 Months, 6 Months
Changes in C-reactive Protein Level (CRP)
Changes in Systemic Inflammation
Time frame: Baseline, 3 Months, 6 Months
Plan to share: No — Individual Participant Data (IPD) will not be shared with other researchers. Only de-identified, cumulative data (summary-level results) will be shared with the study sponsor (OraPharma) after study completion. No identifiable participant information such as name, date of birth, or contact details will be disclosed. All collected data will remain securely stored within Case Western Reserve University and will only be accessed by the study investigators and authorized university or regulatory personnel.
Started Feb 2026 (actual). Primary completion is estimated for Jun 2027, 16 months after the start.
Of 27 phase 1 interventional studies under Periodontitis, half reached primary completion within 12 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 19. This study's planned 16 months is above that.
How these figures are worked out, and which studies are left out of them.
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