An interventional study of Non-surgical periodontal therapy will be administered in Obesity and Periodontitis, sponsored by Louisiana State University Health Sciences Center in New Orleans. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-28.
Sponsored by Louisiana State University Health Sciences Center in New Orleans · Not applicable, Interventional, and Basic science
The goal of this study is to investigate the long-term changes in host epigenetic modifications in obese individuals with periodontitis. The aims of the study are:
Periodontitis is an inflammatory disease process primarily caused by microorganisms, which affects the tooth-supporting structures and can eventually lead to tooth loss. Oral health is a reflection of general health. Accordingly, obesity can influence periodontitis and increase its severity. The study participants will be categorized into two groups as described above. Enrolled participants will be balanced for distribution of age, gender, ethnicity, and general health.
The objective of this pilot study is to investigate the cross-sectional and longitudinal changes in host epigenetic modifications in obese individuals with periodontitis. The investigators intend to examine these host epigenetic changes in obese and non-obese individuals with both periodontal health and periodontitis. The study will primarily evaluate longitudinal changes following non-surgical periodontal therapy (considered the gold standard for the initial treatment of periodontitis) to determine whether any modifications occur with treatment.
To control for other factors affecting periodontitis, the investigators plan to exclude diabetic participants, document oral hygiene habits, and monitor periodontal microorganisms and inflammatory mediators in the groups for further associations. In summary, the study will identify important epigenetic signatures in obese participants with periodontal disease compared to those with periodontal health as a potential causal factor linking the two conditions.
The investigators hypothesize that epigenetic programs in obese individuals will influence the severity of periodontal disease by altering inflammatory pathways and the microbial environment.
11,522 studies on the registry are indexed under Obesity; 2,033 are open to participants now.
This study's planned enrollment of 40 is below the median of 67 across 9,006 interventional studies indexed under Obesity.
Browse Obesity studies →Louisiana State University Health Sciences Center in New Orleans is the lead sponsor of 72 studies on the registry; 12 are open to participants now.
Of its 7 completed or terminated interventional studies of FDA-regulated products, 1 (14%) have results posted.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Non-surgical periodontal therapy will be administered
Procedure: Non-surgical periodontal therapy will be administered
Non-surgical periodontal therapy will be administered
Procedure: Non-surgical periodontal therapy will be administered
Non-surgical periodontal therapy (Deep cleaning-SRP): The deep cleaning by a scaling and root planing (SRP) procedure, is the standard initial treatment for all individuals diagnosed with periodontitis (periodontal disease). At the initial treatment planning appointment, each subject will receive intra-oral and extra-oral examination along with full mouth examination of the periodontal status, followed by diagnosis and treatment planning. The subject will then be scheduled for a deep cleaning procedure. The Deep cleaning procedure are carried out using hand instruments and ultrasonic instruments.
Also known as: Scaling and root planing
Host-specific epigenetic signatures
Gingival crevicular fluid and saliva will be analyzed to study epigenetic signatures
Time frame: Baseline/Day 1
Inflammatory cytokine profiles
Gingival crevicular fluid and saliva will be analyzed to study inflammatory cytokine profiles.
Time frame: Baseline/Day 1
Periodontal microbial composition
Subgingival plague will be analyzed to study periodontal microbial composition
Time frame: Baseline/Day 1
Host epigenetic modifiers pre- and post-therapy
Gingival crevicular fluid and saliva will be analyzed to study epigenetic changes.
Time frame: Baseline/Day 1, Day 30, Day 90
Inflammatory cytokine changes pre- and post-therapy
Gingival crevicular fluid and saliva will be analyzed to study inflammatory cytokine changes.
Time frame: Baseline/Day 1, Day 30, Day 90
Periodontal microbial changes pre- and post-therapy
Subgingival plague will be analyzed to study periodontal microbial changes.
Time frame: Baseline/Day 1, Day 30, Day 90
Plan to share: No — Aggregated data will be published as a peer reviewed manuscript.
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Louisiana State University Health Sciences Center in New Orleans