An interventional study of EEG-NIRS protocol and Questionnaire in Williams Syndrome, Language and Phonological Short-Term Memory, sponsored by Centre Hospitalier Universitaire, Amiens. Recruiting at 1 site in France. Open to participants aged 6 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-16.
Sponsored by Centre Hospitalier Universitaire, Amiens · Not applicable, Interventional, and Basic science
Williams syndrome (WS) is a neurodevelopmental disease characterized by mild to moderate intellectual disability and an extremely heterogeneous cognitive profile. Research has outlined two main features of WS: an atypical social behavior associated with surprising language abilities, and a hyperacusis. The purpose of this project is to investigate the relationships between both these abilities, and particularly the role of the hyperacusis on language abilities. The hyperacusis would be crucial in developing language skills: the apparent strength in the verbal domain could rely on Phonological Short Term Memory (PSTM) more in individuals with WS than in typically developing individuals. In addition, the investigators will compare individuals with WS to individuals with Down syndrome (DS): DS is often associated to strong limitations in the PSTM with poor language abilities. To this end, the investigators will use a highly innovative approach including physiological assessments (EEG-NIRS protocol) and questionnaires. The performance of people with WS will be compared to those of participants with DS and TD participants of same DA and cognitive assessments.
29 studies on the registry are indexed under Williams Syndrome; 11 are open to participants now.
This study's planned enrollment of 130 is above the median of 60 across 12 interventional studies indexed under Williams Syndrome.
Browse Williams Syndrome studies →Centre Hospitalier Universitaire, Amiens is the lead sponsor of 586 studies on the registry; 185 are open to participants now.
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Exclusion Criteria:
Other: EEG-NIRS protocol · Other: Questionnaire
Other: EEG-NIRS protocol · Other: Questionnaire
Other: EEG-NIRS protocol · Other: Questionnaire
Other: EEG-NIRS protocol · Other: Questionnaire
Each participant will be tested individually in a quiet room at the GRAMFC (Groupe de Recherches sur l'Analyse Multimodale de la Fonction Cérébrale, INSERM-UMR1105, Université Picardie Jules Verne and CHU Amiens-Picardie). Duration of subject's participation in the study is 120 minutes
Each participant will be tested individually in a quiet room at the GRAMFC (Groupe de Recherches sur l'Analyse Multimodale de la Fonction Cérébrale, INSERM-UMR1105, Université Picardie Jules Verne and CHU Amiens-Picardie). Duration of subject's participation in the study is 120 minutes
questionnaire score of patients with WS caracterisation
questionnaire score for cognitive profile of patients with WS caracterisation
Time frame: 2 years
Impact of hyperacusis on questionnaire score
Impact of hyperacusis on questionnaire score
Time frame: 2 years
Plan to share: No
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