Williams Syndrome clinical trials
The registry lists 29 studies for Williams Syndrome across 6 countries. 11 are recruiting or about to start. 22 of them are mainly about Williams Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-29.
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Breast cancer · Recruiting: 2 came in, 3 changed
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A study of drug A after surgery for early breast cancer
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· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Status
Who runs them
National Heart, Lung, and Blood Institute (NHLBI) (3) · Massachusetts General Hospital (3) · Hospices Civils de Lyon (3) · Qilu Hospital of Shandong University (3) · Sheba Medical Center (2) · Sanford Health (1) · National Center for Research Resources (NCRR) (1) · University of North Carolina, Chapel Hill (1)
What is being tested here
Drugs under test in Williams Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Methylphenidate | 1 | 0 | 1 |
| Fluoxetine | 1 | 0 | 1 |
| Risperidone | 1 | 0 | 1 |
| Clemastine | 0 | 0 | 1 |
| Minoxidil | 0 | 0 | 1 |
| Buspirone | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Dec 2026Research on the Molecular Mechanism of Cognitive Differences Between Williams Syndrome and Autism Spectrum Disorder · Qilu Hospital of Shandong University
- Jan 2027A Case-Control Observational Study of Peripheral Blood-Derived iPSC Models to Investigate Oligodendrocyte Lineage Development in Children With Williams Syndrome and Healthy Controls · Qilu Hospital of Shandong University
- Aug 2027The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome · The Chaim Sheba Medical Center
Who these studies take
Of the 8 Williams Syndrome studies recruiting now, 6 (75%) set no upper age limit and 1 (13%) stop at 75 or younger. 6 (75%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (50%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 6 (75%) | 6 (75%) |
| 18 | 7 (88%) | 7 (88%) |
| 30 | 7 (88%) | 7 (88%) |
| 40 | 7 (88%) | 7 (88%) |
| 50 | 7 (88%) | 7 (88%) |
| 65 | 7 (88%) | 7 (88%) |
| 75 | 7 (88%) | 7 (88%) |
| 85 | 7 (88%) | 7 (88%) |
Across all 29 studies, recruiting or not: 55% stop at 75 or younger and 45% at 65; 83% take children; 0% are for women only and 0% for men only; 45% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 29 of 29. search them.
- Defining the Brain Phenotype of Children With Williams SyndromeRecruitingNCT011328851 country
- Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordRecruitingNCT017931681 country
- Parent and Infant Inter(X)Action Intervention (PIXI)Enrolling by invitationNCT03836300Not applicable1 country
- Characterization and Natural History of Williams Syndrome and Other Chromosome 7q11.23 VariantsRecruitingNCT069304171 country
- A Case-Control Observational Study of Peripheral Blood-Derived iPSC Models to Investigate Oligodendrocyte Lineage Development in Children With Williams Syndrome and Healthy ControlsNot yet recruitingNCT07537374
- Research on the Molecular Mechanism of Cognitive Differences Between Williams Syndrome and Autism Spectrum DisorderNot yet recruitingNCT075098791 country
- Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal DisordersRecruitingNCT074930961 country
- The Psychiatric and Cognitive Phenotypes in Velocardiofacial SyndromeRecruitingNCT00768820Phase 41 country
- Physical Activity and Community EmPOWERment ProjectRecruitingNCT06740162Not applicable1 country
- Phonological Constraints on Language Development in Individuals With Williams SyndromeRecruitingNCT07285720Not applicable1 country
- GROWing Up With Rare GENEtic SyndromesRecruitingNCT044633161 country
- WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study)CompletedNCT026928461 country
- Impact of Elastin Mediated Vascular Stiffness on End OrgansCompletedNCT028404481 country
- Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue BankCompletedNCT027066391 country
- Clemastine Fumarate in the Treatment of Neurodevelopmental Delays in Williams SyndromeCompletedNCT06315699Phase 21 country
- Clemastine Treatment in Individuals With Williams SyndromeActive, not recruitingNCT06087757Phase 21 country
- Efficacy of Minoxidil in Children With Williams-Beuren SyndromeCompletedNCT00876200Phase 21 country
- Buspirone Treatment of Anxiety in Williams SyndromeCompletedNCT04807517Phase 41 country
- Motor Deficits and Signal Conduction in Individuals With Williams SyndromeWithdrawnNCT054307631 country
- Williams Syndrome Strength, Hormones, Activity & Adiposity, DNA Programming, Eating StudyCompletedNCT037586511 country
- Effects of Emotion on Episodic Memory in Typically Developing Children and Children With Williams-Beuren SyndromeCompletedNCT03688516Not applicable1 country
- Cooperative Parent Mediated Therapy in Children With Fragile X Syndrome and Williams SyndromeStatus unknownNCT04610424Not applicable1 country
- Cognitive and Behavioral Therapy of Anxiety in Williams SyndromeStatus unknownNCT038275251 country
- Molecular Characterization of Patients Affected by Williams Syndrome and Autism.CompletedNCT04095585
- Quantification of Elastin Markers Synthesis in Williams-Beuren Syndrome and 7q11.23 Micro-duplication SyndromeStatus unknownNCT04051086Not applicable1 country
- Response Inhibition Training for Children With Williams SyndromeCompletedNCT02212314Not applicable1 country
- Fat Distribution and Glucose Metabolism in Williams SyndromeCompletedNCT018643041 country
- Vitamin D Metabolism and the Williams SyndromeCompletedNCT000139621 country
- Study of Phenotype and Genotype Correlations in Patients With Contiguous Gene Deletion SyndromesCompletedNCT000043511 country