An observational study in Respiratory Insufficiency in Children, sponsored by Brno University Hospital. Recruiting at 1 site in Czechia. Open to participants aged 1 Year to 18 Years. Per ClinicalTrials.gov, last updated 2026-03-12.
Sponsored by Brno University Hospital · Observational
Transcutaneous capnometry (tPCO₂) is a non-invasive method for continuous monitoring of ventilation status. In pediatric intensive care patients, it may reduce the need for repeated arterial or arterialized blood sampling. However, the accuracy of tPCO₂ may be influenced by factors such as peripheral perfusion, skin temperature, and vasopressor therapy. This prospective observational study compares transcutaneous carbon dioxide measurements with arterialized or arterial blood gas PaCO₂ values in children with respiratory insufficiency, including a subgroup receiving vasopressor support.
This prospective observational study will be conducted in a pediatric intensive care unit to assess agreement between transcutaneous carbon dioxide monitoring and arterialized or arterial blood gas analysis. Consecutive pediatric patients aged 1-18 years with respiratory insufficiency or impaired peripheral perfusion requiring vasopressor support will be included if repeated blood gas sampling is clinically indicated.
Paired measurements of tPCO₂ and PaCO₂ will be analyzed using Bland-Altman methods with correction for repeated measures. Subgroup analyses will evaluate the influence of vasopressor therapy on measurement accuracy. Secondary analyses will compare tPO₂ and PaO₂ values. The study aims to define the clinical applicability and limitations of transcutaneous capnometry in critically ill pediatric patients.
1,369 studies on the registry are indexed under Respiratory Insufficiency; 264 are open to participants now.
This study's planned enrollment of 20 is below the median of 100 across 455 observational studies indexed under Respiratory Insufficiency.
Browse Respiratory Insufficiency studies →Brno University Hospital is the lead sponsor of 91 studies on the registry; 22 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Critically ill pediatric patients admitted to a tertiary PICU with respiratory insufficiency or circulatory compromise.
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Exclusion Criteria:
Partial CO2 difference
Agreement between transcutaneous CO₂ (tPCO₂) and arterialized or arterial PaCO₂ assessed using Bland-Altman analysis (bias, SD, 95% limits of agreement).
Time frame: periprocedural
Proportion of pCO2
Proportion of tPCO₂ values within ±1 kPa of PaCO₂
Time frame: periprocedural
Partial O2
Agreement between transcutaneous oxygen (tPO₂) and PaO₂
Time frame: periprocedural
Vassopressor use
Subgroup analysis based on presence of vasopressor support
Time frame: periprocedural
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Brno University Hospital