An observational study in Azoospermia, Nonobstructive, sponsored by IRCCS San Raffaele. Recruiting at 1 site in Italy. Open to male participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2023-12-26.
Sponsored by IRCCS San Raffaele · Observational
The study aims to carry out a translational analysis of the microbiome and metabolomics in patients suffering from non-obstructive azoospermia, with the aim of investigating prognostic factors predictive of the possible finding of spermatozoa following testicular pulp extraction and differences in blood and seminal level with the fertile population to identify etiopathogenic pathways of this condition.
The study aims to carry out a translational analysis of the microbiome and metabolomics in patients suffering from non-obstructive azoospermia, with the aim of investigating prognostic factors predictive of the possible finding of spermatozoa following testicular pulp extraction and differences in blood and seminal level with the fertile population to identify etiopathogenic pathways of this condition.
Furthermore, the study aims to assess if the blood and seminal alterations of infertile patients have similarities with the same fluids of elderly patients, validating from a metabolomic and microbiomic point of view the hypothesis of premature aging of infertile patients.
23 studies on the registry are indexed under Azoospermia, Nonobstructive; 7 are open to participants now.
This study's planned enrollment of 45 is below the median of 94 across 10 observational studies indexed under Azoospermia, Nonobstructive.
Browse Azoospermia, Nonobstructive studies →IRCCS San Raffaele is the lead sponsor of 453 studies on the registry; 234 are open to participants now.
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Exclusion Criteria:
Patients diagnosed with idiopathic non-obstructive azoospermia
Other: Analysis of microbiome and metabolomics
fertile subjects (pregnancy within 12 months of the start of the research by the couple, according to WHO 2010 criteria)
Other: Analysis of microbiome and metabolomics
Subjects known to have been fertile subjects (pregnancy within 12 months of the start of the research by the couple, according to WHO 2010 criteria)
Other: Analysis of microbiome and metabolomics
Analysis of microbiome and metabolomics through the assessment of blood and semen parameters
Prognostic role of the blood and semen samples
Metabolomics and microbiome signature fertile and infertile men predicting possible finding of spermatozoa
Time frame: Baseline
Plan to share: No
No publications or documents are linked to this record.
Started Jun 2016 (actual). Primary completion is estimated for May 2026, 119 months after the start.
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