A Phase 3 interventional study of Total Active Prevention Fresh Toothpaste + Colgate Total Active Prevention Battery Toothbrush and Colgate Great Regular + Total Active Prevention Battery Toothbrush in Plaque and Gingivitis, sponsored by Colgate Palmolive. Completed at 1 site in Puerto Rico. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-21.
Sponsored by Colgate Palmolive · Phase 3, Interventional, and Treatment
A clinical research study design to compare the effectiveness of a battery toothbrush and dentifrice in reducing gingivitis and dental plaque in adults.
This is a Phase III, randomized, single-center, parallel group, triple blind, clinical research study design to compare the effectiveness of a battery toothbrush and dentifrice in reducing gingivitis and dental plaque in adults. This study will have 3 arms to determine the efficacy of a battery toothbrush vs a positive control regimen and a negative control regimen to reduce plaque and gingivitis.
89 studies on the registry are indexed under Plaque, Amyloid; 37 are open to participants now.
This study's enrollment of 130 is above the median of 110 across 63 interventional studies indexed under Plaque, Amyloid.
Browse Plaque, Amyloid studies →Colgate Palmolive is the lead sponsor of 114 studies on the registry; 12 are open to participants now.
Of its 33 completed or terminated interventional studies of FDA-regulated products, 2 (6%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
instructed to brush their teeth for two (2) minutes twice a day (morning and evening) with the toothpaste and toothbrush provided.
Drug: Total Active Prevention Fresh Toothpaste + Colgate Total Active Prevention Battery Toothbrush
instructed to brush their teeth for two (2) minutes twice a day (morning and evening) with the toothpaste and toothbrush provided.
Drug: Colgate Great Regular + Total Active Prevention Battery Toothbrush
instructed to brush their teeth for two (2) minutes twice a day (morning and evening) with the toothpaste and toothbrush provided.
Drug: Colgate Great Regular + standard reference flat trim toothpaste
0.454 Stannous Fluoride toothpaste with battery toothbrush
regular fluoride toothpaste with battery toothbrush
regular fluoride toothpaste with manual toothbrush
Löe and Silness Gingival Index
score from 0 to 3 will be assigned by the examining dentist to all scorable surfaces of the maxillary and mandibular teeth using a dental light and dental mirror. A whole mouth mean score for each subject will be determined by adding the values given by the examining dentist to each scorable surface and dividing that number by the total number of surfaces scored.
Time frame: baseline,6 week, 12 week
Rustogi Mod. Navy Plaque Index
An expanded form of the Rustogi Modified Navy Plaque Index, used to measure plaque on different surfaces of teeth. Plaque disclosing solution used
Time frame: baseline, 6 week, 12 week
This study is completed, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Colgate Palmolive