ClinicalTrials.gg
Not yet recruitingNCT07208123Updated Oct 6, 2025

Mechanistic Studies of Chronic COPD Using Single-Cell Sequencing and Single-Cell Spatial Transcriptomics

An observational study in COPD, sponsored by Tongji University. Not yet recruiting at 1 site in China. Per ClinicalTrials.gov, last updated 2025-10-06.

Sponsored by Tongji University · Observational

Study type
Observational
Model
Other
Time perspective
Other
Enrollment
150
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 403 studies in Pulmonary Disease, Chronic Obstructive with a site in China — 107 open to participants now, 124 under way, 15 of them phase 3. Pulmonary Disease, Chronic Obstructive · China.

Planned enrollment
84th of 117
150 · median 500
Started
2025
with 41 others
Observational
117 of 403
40 open now
Primary completion
2026-12
later than 51 of 123 live
Registered
355th of 403
by date

Among the 403 studies in Pulmonary Disease, Chronic Obstructive with a site in China, this one is the 84th largest by planned enrollment of the 117 observational ones, is one of 42 that started in 2025, is one of 117 observational ones, reaches primary completion later than 51 of the 123 other live ones, and was the 355th registered.

By phase

403 studies; the count open now beside each. This study's row is marked.

No phase120 · 31 open
Observationalthis study117 · 40 open
Phase 363 · 13 open
Phase 233 · 13 open
Phase 433 · 3 open
Phase 128 · 4 open
Phase 1/26 · 2 open
Phase 2/33 · 1 open

By the year they started

First in 2000; this study’s year is marked. 42 started in 2025.

Size and results

Median enrollment 155 across the 286 interventional studies, 500 across the 117 observational. Of the 183 that completed or were terminated, 47 (26%) have results posted.

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Watch this landscapeDownload CSVWith an account: a weekly mail of what changed among 403 studies in Pulmonary Disease, Chronic Obstructive with a site in China, or all of them as a file.
02

Study summary

This study is an ambispective cohort study, the sample from patients were from both previously stored and freshly collected . The objective of this study is to investigate the molecular pathological changes underlying the development of chronic obstructive pulmonary disease (COPD). We will use single cell sequencing technology to analyze lung tissue samples from patients who underwent lung resection, with lung tissue from patients without COPD serving as controls. This research aims to provide insights into the pathogenesis of COPD.

03

Conditions studied

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Sampling method
Non-probability sample

Study population

150

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Receiving lung resection surgery at the hospital for any reason;
  • Diagnosed with according to the 2024 GOLD guidelines;
  • Tissue samples that meet collection requirements and are either agreed to be collected or already preserved;

Exclusion criteria

Exclusion Criteria:

  • Improper preservation of pathological specimens, refusal to consent to sample collection, or incomplete clinical information;
  • Combined with other factors causing obstructive airflow limitation;
  • Diagnosed with asthma according to the GINA 2023 guidelines and with a history of asthma exacerbations within the past year;
  • Combined with Advanced lung cancer;
  • Receiving systemic medications such as anti-rejection drugs;
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

COPD

Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.

Immunosuppression

A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.

Read whether the line is about a condition or about medicines, and which medicines and doses it means.

05

Study design

Observational model
Other
Time perspective
Other
Enrollment
150 participants (estimated)
Patient registry
No

Groups and cohorts

  • COPD group
06

What researchers measure

Primary outcomes

  1. Transcriptomic profile analysis of lung tissues

    Time frame: until end of surgery

07

Study locations

1 site
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Start is estimated for Sep 2025; primary completion for Dec 2026, 15 months later.

Of 466 non-industry observational studies under Pulmonary Disease, Chronic Obstructive, half reached primary completion within 29 months of starting (the median), counting those still running; a quarter within 15 and three quarters within 64. This study's planned 15 months is below that.

Counting every sponsor, half of 586 studies reached it within 26 months; a quarter within 14 and three quarters within 58.

How these figures are worked out, and which studies are left out of them.

Registered
Sep 27, 2025
First posted
Oct 6, 2025
StartEst.
Sep 30, 2025
Primary completionEst.
Dec 31, 2026
CompletionEst.
Dec 31, 2027
Last update
Oct 6, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Oct 6, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07208123
Lead sponsor
Tongji University
Responsible party
Fang Chen (professor, Tongji University) — Principal investigator
First posted
Oct 6, 2025
Start date
Sep 30, 2025 (estimated)
Primary completion
Dec 31, 2026 (estimated)
Completion
Dec 31, 2027 (estimated)
Last update
Oct 6, 2025

Study contacts

Feng Xinyu, Dr
Contact
52290946015@stu.ecnu.edu.cn
86-17621694653
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.

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Discussion

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