ClinicalTrials.gg
Active, not recruitingNCT07187596MOCH1Updated Jul 29, 2026

Mortality Outcome of Controlled Hypertension

An observational study in Hypertension, Morality and Death, sponsored by DejthidaNathaphong. Active, not recruiting at 1 site in Thailand. Open to participants aged 1 Minute to 130 Years. Per ClinicalTrials.gov, last updated 2026-07-29.

Primary conditionPre-EclampsiaRegistry: HypertensionReclassifiedWhy we changed it
Registry
Hypertension — the first condition term the registry derived for this study.
ClinicalTrials.gg
Pre-Eclampsia
Why
  1. The study's listed conditions name Pre-Eclampsia, a narrower term within Hypertension.
Confidence
High: the new condition is named in the study's own listed conditions. Of 351 hand-checked studies reclassified this way, 68% were exactly right and 84% in the right disease family; the registry's first term was right for 5% (measured 2026-10-21). How we classify →
Wrong?
Tell us the study's main condition →

Sponsored by DejthidaNathaphong · Observational

Study type
Observational
Model
Other
Time perspective
Other
Enrollment
2,547
Ages
1 Minute to 130 Years
Sex
All
01

Study summary

This review focuses on the assumption of mortality outcome of participants remaining label hypertension care is adequately managed when pressure targets are met with both qualitative and quantitaive method.

Read the detailed description

For systematically review and synthesize the literature on main 2 questions

  1. Why do mortality outcomes still occur despite intervention of high blood pressure?
  2. What is the framework of high blood pressure death?

For Individual Participant Data Meta-analysis will be attracted from final analysis articles from the framework of data selection process only, the effect measurement and multi-variable model meta-analysis will be performed.

Sub-group analysis effect measurement following;

  • Types and causes of death in patients with well-controlled hypertension.
  • Underlying evidence or proposed mechanisms, biological markers, or comorbid conditions contribute to death despite optimal treatment.
  • Treatment-related limitations, co-factors, and syndromes leading to uncontrolled fatal outcomes.
  • Analyze possible mechanisms of cardiovascular death in controllable even intensive blood pressure control participants.
02

Conditions studied

  • Hypertension
  • Morality
  • Death
  • Pre-Eclampsia
  • Cardiovascular Diseases
  • Stroke
  • Renal Disease
  • Artery Stenosis
  • Arterial Aneurysm
  • Arterial Rupture
  • Maternal Death

Keywords

  • Controlled blood pressure
  • Mortality outcomes
03

In context

Pre-Eclampsia Reclassified

916 studies on the registry are indexed under Pre-Eclampsia; 243 are open to participants now.

This study's planned enrollment of 2,547 is above the median of 165 across 397 observational studies indexed under Pre-Eclampsia.

Browse Pre-Eclampsia studies →

Lead sponsor

DejthidaNathaphong is the lead sponsor of 4 studies on the registry; 2 are open to participants now.

Compared within Pre-Eclampsia, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Hypertension. The counts are of registry records indexed under each term, refreshed daily. How we classify →

04

Who can participate

Ages eligible
1 Minute to 130 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Studies including patients (any age or sex) with:

  • Interventional treatment for hypertension
  • Documented blood pressure control (as defined by each primary study)
  • Reported mortality or fatal outcome

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Human birth in all sex chromosomes.

    • Study reports evidence of living with owned systemic/arterial hypertension by one of definition following;

      • Quantitative: Blood pressure number higher over the normal range by each protocol in mmHg unit in any arm of study.
      • Qualitative: Clarify the underwent both retrospective, observation or intervention of blood pressure and clearly clarify number of hypertension participants in article.
    • Study design: any type of studies and have a doi number.

      • In case report type study, the article recruit in only high blood pressure is a burden that reports both direct intervention for blood pressure or indirect intervention such as treatment of vascular damage from high blood pressure.
      • In a group of literature review type study, the number of hypertension participants with references from both in supplementary document or traced back via each doi number have to clearly declare in that free full-text and currently non-retracted article without personal requirement as raw material to processing the individual participant data meta-analysis
    • Study recruit only last version of study series that have to confirm published the hypertension participant with mortality outcomes.
    • English-language studies.

Exclusion criteria

  • Non human/human-specimen studies.

    • Evidence confirms local site or specific system hypertension only such as studies of pulmonary hypertension, portal hypertension, ocular hypertension without clearly defining the number of systemic arterial hypertension in articles.
    • No report of conclusion of participant such as no mortality report, no failed/successful outcome from last follow up from hypertension associated life-threatening event.
    • Deaths due to suicide, trauma, or illegal drugs including intend to take medication overdose in any reason.
    • Book, Testimonial, Interview, Conference, Protocol articles.
    • Sub-group analysis.
    • Duplicate one of the doi/nct/prospero numbers.
    • No doi. Number
05

Study design

Observational model
Other
Time perspective
Other
Enrollment
2,547 participants (estimated)
Target follow-up
1 Year
Patient registry
Yes

Groups and cohorts

  • Mortality outcomes

    Mortality outcomes or casue which mainly suspected from hypertension

06

What researchers measure

Primary outcomes

  1. All-cause vascular mortality

    Cardiovascular mortality (Cardiac-related death in controlled hypertension patients), cerebrovascular death(Stroke-related fatal outcomes in BP-controlled patients), renal occlusion/rupture/failure causing death (Mortality from renal failure in treated, controlled hypertensives), life-threatening vascular rupture, Major Adverse Cardiovascular Death or

    Time frame: Day one until last follow up at least 24 hour to study completion date at least 30 days outcomes but not over 10 years

Secondary outcomes

  1. Sudden death

    Death suddenly with autopsy or complete CPR during collapse of cardiac or respiratory or brain arrested

    Time frame: Day one until last follow up at least 24 hour to study completion date at least 30 days outcomes but not over 10 years

  2. End-organ failure leading to death

    Vascular abnormality causing failure of organ leading death with evidence by imaging, laboratory investigation or autopsy

    Time frame: 90 days outcomes after participant recruitment (death/alive)

  3. ICU death

    Systemic arterial hypertension is the main reason for admission at critical care unit report death

    Time frame: 90 days outcomes start with day 1 admit at ICU (death/alive)

  4. Maternal associated hypertension death

    Mortality outcomes of hypertension during pregnancy both from gynecologic organ failure or systemic organ failure

    Time frame: During pregnancy period from GA 1 week to delivery (pre-term, term-post-term) to 6 week follow up postpartum

  5. Hypertension associated death in the young

    Mortality outcomes that clear defined high blood pressure of that age and declared mortality cause during or after any type of treatment

    Time frame: Day one until last follow up at least 24 hour to study completion date at least 30 days outcomes but not over 18 years of ages of participant

07

Study locations

1 site
  • Owned study
    Bangkok, Bangkok 10110, Thailand
08

References and documents

Study documents

PDFs hosted by the registry, ClinicalTrials.gov.

Individual participant data

Plan to share: Yes — The study already registered from PROSPERO number CRD420251072526

Supporting information: Study protocol, Statistical analysis plan, Clinical study report, Analytic code

Time frame: TIMELINE OF THE REVIEW Date of first submission to PROSPERO 01 July 2025 Review timeline Start date: 14 June 2025. End date: 31 December 2026. Date of registration in PROSPERO 01 July 2025

Access criteria: Public registered

Data sharing details ↗ · www.crd.york.ac.uk

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 29, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07187596
Lead sponsor
DejthidaNathaphong
Responsible party
Nathaphong Dejthida (Principle Investigator, DejthidaNathaphong) — Principal investigator
First posted
Sep 23, 2025
Start date
Sep 18, 2025
Primary completion
Dec 18, 2026 (estimated)
Completion
Dec 14, 2027 (estimated)
Last update
Jul 29, 2026

Study contacts

Nathaphong Dejthida, MD
principal investigator · DejthidaNathaphong

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion