An interventional study of Synovial Fluid withdrawal at the preoperative clinic visit and Platelet-Rich Plasma (PRP) preparation and injection in Posttraumatic Osteoarthritis and Anterior Cruciate Ligament (ACL) Rupture, sponsored by Rush University Medical Center. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-06-18.
Sponsored by Rush University Medical Center · Not applicable, Interventional, and Other
The purpose of this study is to determine what effects the withdrawal of excess knee joint fluid or the injection of a factor from the blood has on swelling after a sudden anterior cruciate ligament (ACL) rupture of the knee.
The body responds to different stresses by releasing factors in the blood and fluids in response to stressors like injury, surgery or certain treatments. Some of these factors help heal and some make the injury and body swell (inflammation). In this study we want to see if the intervention of withdrawing fluid the knee or the addition of an enriched healing factor called platelet rich plasma (PRP) injected in the knee influences the body to produce healing factors in the knee joint fluid.
78 studies on the registry are indexed under Rupture; 17 are open to participants now.
This study's planned enrollment of 99 is above the median of 71 across 44 interventional studies indexed under Rupture.
Browse Rupture studies →Rush University Medical Center is the lead sponsor of 397 studies on the registry; 61 are open to participants now.
Of its 32 completed or terminated interventional studies of FDA-regulated products, 26 (81%) have results posted.
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Subjects randomized to Arm 1 will have 2 synovial fluid withdrawals; one at the preoperative clinic visit and one at the time of surgery
Procedure: Synovial Fluid withdrawal at the preoperative clinic visit · Procedure: Synovial fluid withdrawal at the time of surgery
Subjects randomized to ARM 2 will have 2 synovial fluid withdrawals one at the preoperative visit and one at the time of surgery. Platelet-Rich Plasma (PRP) preparation and injection will happen at the preoperative clinic visit.
Procedure: Synovial Fluid withdrawal at the preoperative clinic visit · Procedure: Platelet-Rich Plasma (PRP) preparation and injection · Procedure: Synovial fluid withdrawal at the time of surgery
Subjects randomized to Arm 3 will have 3mL withdrawal of synovial fluid at the preoperative visit and 1 synovial fluid withdrawal at the time of surgery
Procedure: Synovial fluid withdrawal at the time of surgery · Procedure: 3mL synovial fluid withdrawn at the preoperative visit
Synovial Fluid withdrawal at the preoperative clinic visit
Also known as: arthrocentesis
Platelet-Rich Plasma (PRP) preparation and injection
Also known as: platelet rich plasma
Synovial fluid withdrawal at the time of surgery
3mL synovial fluid withdrawn at the preoperative visit
Concentration of Collagen Type II Cytokine
Breakdown cytokine found in damaged cartilage
Time frame: Enrollment up to surgery
Start is estimated for Sep 2026; primary completion for Oct 2028, 25 months later.
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This study is not yet recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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