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CompletedNCT07084857Updated Apr 8, 2026

Association Between Isokinetic Lower Extremity Muscle Strength and Bone Mineral Density in Elderly Women With and Without Osteoporosis

An observational study in Osteoporosis, sponsored by Cairo University. Completed at 1 site in Egypt. Open to female participants aged 50 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-04-08.

Sponsored by Cairo University · Observational

Study type
Observational
Model
Case-only
Time perspective
Cross-sectional
Enrollment
70
Ages
50 Years to 70 Years
Sex
Female
01

Study summary

bone density and muscle strength appear to be more related to each other. Examining the association between muscle strength and bone health is very important in recognizing risk factors for lower extremity muscle weakness.

Read the detailed description

Dual Energy X-ray Absorptiometry (DEXA) scan will be used to assess hip bone mineral density (BMD) at femoral head region. Isokinetic PT of hip flexors, extensors, abductors and adductors and knee flexors and extensors will be measured using Biodex System 3 Isokinetic Dynamometer. The measured outcomes will be evaluated at an angular velocity of 60°/sec in a concentric mode of muscle contraction for five successive repetitions. Isokinetic testing will be done at the Isokinetic Laboratory, Faculty of Physical therapy, Cairo University.

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Conditions studied

  • Osteoporosis

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Keywords

  • Osteoporosis
  • Bone Mineral Density
  • Isokinetic Strength;
  • Hip Muscles
  • Knee Muscles
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In context

Osteoporosis

1,640 studies on the registry are indexed under Osteoporosis; 212 are open to participants now.

This study's enrollment of 70 is below the median of 174 across 446 observational studies indexed under Osteoporosis.

Browse Osteoporosis studies →

Lead sponsor

Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.

Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
50 Years to 70 Years
Sexes eligible
Female
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Based on a sample size calculation via G Power software, a total of 70 participants will be required to participate in the study taking in consideration 20% drop out. A total 66 elderly women with ages range from 50 to 70 years will be involved in the study

Inclusion criteria

  1. The group of OP (n=33) has femoral BMD T-scores below -2.5 diagnosed by DEXA scan according to the WHO [8] classification of BMD in 2003,
  2. The control group has normal BMD T-scores more than -1.

Exclusion criteria

Exclusion Criteria:

  1. There was any neurological, musculoskeletal, rheumatologic, respiratory or cardiovascular problem.
  2. They were receiving medications that result in bone loss such as corticosteroids,
  3. They had vertigo, dizziness, or any vestibular problem,
  4. They had hyperthyroidism or hyperparathyroidism. 6- They actively participate in sports activities,
  5. They underwent previous surgery (e.g; joint replacement) or history of fractures of the lower extremity.
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Study design

Observational model
Case-only
Time perspective
Cross-sectional
Enrollment
70 participants (actual)
Patient registry
No

Interventions

  • Othercorrelational analysis between BMD and isokinetic lower extremity strength

    correlational analysis between BMD and isokinetic lower extremity strength

06

What researchers measure

Primary outcomes

  1. isokinetic strength of hip muscles

    isokinetic hip muscle stregth will be measured using Biodex system 3 Isokinetic Dynamometer

    Time frame: one month

  2. Bone mineral density

    bone mineral density measured by dual energy x ray absorptiometry scan

    Time frame: one month

Secondary outcomes

  1. isokinetic strength of knee muscles

    isokinetic hip muscle stregth will be measured using Biodex system 3 Isokinetic Dynamometer

    Time frame: one month

07

Study locations

1 site
  • Azza Mohammed
    Giza, 12511, Egypt
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 8, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07084857
Lead sponsor
Cairo University
Responsible party
Azza Mohammed (Prof. Dr, Cairo University) — Principal investigator
First posted
Jul 25, 2025
Start date
Feb 8, 2025
Primary completion
Mar 28, 2025
Completion
Mar 29, 2025
Last update
Apr 8, 2026

Study contacts

Azza M Abdelmohsen, professor
principal investigator · Cairo University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.

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