ClinicalTrials.gg
RecruitingNCT07063147TICM-SCPUpdated Jul 18, 2025

TTE Improves Clinical Management of Stable Chest Pain

An observational study in Transthorcic Echocardiography, Stable Angina Pectoris and Coronary Artery Disease, sponsored by Tianjin Chest Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-07-18.

Sponsored by Tianjin Chest Hospital · Observational

From the registry’s dates

  • Started Jan 2025; still recruiting 1 year 10 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
50,000
Ages
18 Years and older
Sex
All
01

Study summary

The investigator aims to prospectively enroll patients who were referred for transthorcic echocardiography (TTE) for the assessment of stable chest pain (SCP) suspected of obstructive coronary artery disease (CAD). All patients underwent TTE according to established guidelines and local institutional protocols. This study will determine if TTE-based imaging evaluation can provide more informaton to improve clinical management for SCP, including fewer MACE and better decision-making of downstream investigations and therapeutic interventions.

02

Conditions studied

  • Transthorcic Echocardiography
  • Stable Angina Pectoris
  • Coronary Artery Disease
  • Major Adverse Cardiac Events
  • Invasive Coronary Angiography
03

In context

Angina, Stable

343 studies on the registry are indexed under Angina, Stable; 56 are open to participants now.

This study's planned enrollment of 50,000 is above the median of 508 across 103 observational studies indexed under Angina, Stable.

Browse Angina, Stable studies →

Lead sponsor

Tianjin Chest Hospital is the lead sponsor of 9 studies on the registry; 4 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients who were referred for TTE for the assessment of SCP suspected of CAD.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • symptomatic patients with SCP suspected of obstructive CAD.
  • referred for TTE for the assessment of SCP.
  • ≥18 years of age.
  • signed .

Exclusion criteria

Exclusion Criteria:

  • acute coronary syndromes
  • previous CAD or coronary revascularization
  • nonsinus rhythm
  • cardiomyopathy, valvular disease, congenital heart disease or left cardiac insufficiency because of other reasons
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
50,000 participants (estimated)
Target follow-up
10 Years
Patient registry
Yes

Groups and cohorts

  • TTE

    Diagnostic Test: TTE

Interventions

  • Diagnostic testTTE

    All patients underwent TTE according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary.

06

What researchers measure

Primary outcomes

  1. Major adverse cardiovascular events

    Time frame: 10 years

Secondary outcomes

  1. Invasive coronary angiography

    Invasive coronary angiography occurred at follow-up after TTE, attributed to TTE results or unplanned.

    Time frame: 10 years

  2. Medication prescription

    Change for medication prescription of antiplatelet agents, anti-ischemic drugs, lipid-lowering agents, angiotensin-converting enzyme inhibition and so on, attributed to TTE results or unplanned,

    Time frame: 10 years

  3. Coronary revascularization

    PTCA, PCI or CABG occurred at follow-up after TTE, attributed to TTE results or unplanned.

    Time frame: 10 years

07

Study locations

1 of 1 sites recruiting
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Jan 2025 (actual). Primary completion is estimated for Dec 2030, 71 months after the start.

Of 52 observational studies under Angina, Stable, half reached primary completion within 47 months of starting (the median), counting those still running; a quarter within 27 and three quarters within 79. This study's planned 71 months is above that.

How these figures are worked out, and which studies are left out of them.

Registered
Jul 3, 2025
First posted
Jul 14, 2025
StartActual
Jan 1, 2025
Primary completionEst.
Dec 31, 2030
CompletionEst.
Dec 31, 2040
Last update
Jul 18, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jul 18, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07063147
Lead sponsor
Tianjin Chest Hospital
Responsible party
Zhou Jia (Principal Investigator, Tianjin Chest Hospital) — Principal investigator
First posted
Jul 14, 2025
Start date
Jan 1, 2025
Primary completion
Dec 31, 2030 (estimated)
Completion
Dec 31, 2040 (estimated)
Last update
Jul 18, 2025

Study contacts

Jia Zhou
Contact
zhoujiawenzhang@126.com
+8615522485560

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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