An interventional study of Manual Therapy and Therapeutic Exercises Programs in Temporomandibular Disorders (TMDs), sponsored by University of Jaén. Not yet recruiting at 1 site in Spain. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2025-07-09.
Sponsored by University of Jaén · Not applicable, Interventional, and Treatment
Among 40 studies in Temporomandibular Joint Disorders with a site in Spain — 12 open to participants now, 13 under way, none of them phase 3. Temporomandibular Joint Disorders · Spain.
Among the 40 studies in Temporomandibular Joint Disorders with a site in Spain, this one is the 27th largest by planned enrollment of the 32 interventional ones, is one of 5 that started in 2025, is one of 28 with no phase, reaches primary completion later than 3 of the 12 other live ones, and was the 36th registered.
591 studies on the registry are indexed under Temporomandibular Joint Disorders; 149 are open to participants now.
This study's planned enrollment of 30 is below the median of 45 across 415 interventional studies indexed under Temporomandibular Joint Disorders.
Browse Temporomandibular Joint Disorders studies →12 of the 40 studies in Temporomandibular Joint Disorders with a site in Spain are open now, in 12 countries. Each count lists the studies.
Of the 75 Temporomandibular Joint Disorders studies recruiting now, 26 (35%) set no upper age limit and 45 (60%) stop at 75 or younger; 7 take children under 18; 23 take healthy volunteers.
This study: 18 Years to 65 Years · all sexes · no healthy volunteers.
The full table on the hub →40 studies; the count open now beside each. This study's row is marked.
First in 2009; this study’s year is marked. 5 started in 2025.
Median enrollment 53 across the 32 interventional studies, 115 across the 8 observational. Of the 23 that completed or were terminated, 3 (13%) have results posted.
1 of 40 have an industry lead sponsor. The 10 most frequent:
University of Jaén is the lead sponsor of 81 studies on the registry; 2 are open to participants now.
University of Jaén has 4 studies filed under Temporomandibular Joint Disorders — fewer than ten, so there is no comparison to draw.
2 of the studies in Temporomandibular Joint Disorders with a site in Spain that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06265636OrigenKinesis fisioterapiaElectrical Stimulation of the Mandibular Nerve for Pain and Function Management in Temporomandibular Disorders | 2027-01-20 |
| NCT07514208Universitat Internacional de CatalunyaPericranial and General Sensitivity in Patients With Primary Headache | 2027-06 |
Among the 40 studies in Temporomandibular Joint Disorders with a site in Spain, from their registry updates:
Nothing recorded among them since 2026-09-25.
The aim of this study is to evaluate and compare the effects of two physiotherapeutic intervention programs on the quality of life in patients with Temporomandibular Disorders (TMD).
Study design: Randomized, longitudinal, and prospective clinical trial with two intervention groups.
Population: Subjects aged 18-65 years with subacute temporomandibular disorders.
The study will be carried out at the Faculty of Nursing and Physiotherapy of the University of Alcalá. A total of 30 subjects with Temporomandibular Disorders (TMD) will be selected and randomly assigned into two intervention groups.
The first group will receive a physiotherapy treatment based on a Manual Therapy program targeting the orofacial region, combined with a Cervical Therapeutic Exercise program. In contrast, the second group will receive a physiotherapy treatment based on a Manual Therapy program for the orofacial region, combined with an Orofacial Therapeutic Exercise program.
Both groups will undergo a total of six treatment sessions over a period of six weeks (1 session per week). Each manual therapy session targeting the orofacial region will last 30 minutes. The manual therapy (MT) techniques will include a combination of neuromuscular and articular manual techniques.
The study will assess the following variables: quality of life, sleep quality, pressure pain threshold, maximum pain-free mouth opening, perceived pain, and treatment adherence.
Measurements will be taken pre-treatment, post-treatment and a follow-up at 8 weeks
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Subjects in this group will receive physiotherapy treatment consisting of a Manual Therapy program targeting the orofacial region, combined with a Cervical Therapeutic Exercise program. The Cervical Therapeutic Exercise program focuses on co-contraction exercises of the flexor and extensor muscles, progressively increasing difficulty and resistance through the use of a latex band (Theraband), along with neural tissue techniques.
Other: Manual Therapy and Therapeutic Exercises Programs
Subjects in this group will receive physiotherapy treatment consisting of a Manual Therapy program targeting the orofacial region, combined with an Orofacial Therapeutic Exercise program. The Orofacial Therapeutic Exercise program focuses on coordination exercises of the masseter muscles, progressively increasing difficulty and resistance, and is combined with neural tissue techniques.
Other: Manual Therapy and Therapeutic Exercises Programs
A treatment based on the combination of Manual Therapy targeting the orofacial region and a therapeutic exercise program focused on either the cervical or orofacial region
Quality of Life (SF-12)
The SF-12 consists of a subset of 12 items from the SF-36, covering physical functioning, social functioning, physical role, emotional role, mental health, vitality, bodily pain, and general health. The SF-12 is a shortened version of the SF-36 Health Survey. It is a self-administered questionnaire with a completion time of less than 2 minutes. The response options are based on Likert-type scales that assess intensity or frequency. The number of response options ranges from three to six, depending on the item.
Time frame: Pre-intervention, post-intervention (6 weeks) and follow-up of 8 weeks after the end
Sleep Quality (Pittsburgh Sleep Quality Index)
The Pittsburgh Sleep Quality Index (PSQI) is a self-administered instrument designed to assess sleep quality in adults over the past month. It consists of 19 items grouped into seven components: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleep medication, and daytime dysfunction.
Time frame: Pre- intervation, post-intervention (6 weeks) and follow-up of 8 weeks after the end.
Pain Intensity (NRS)
The Numerical Rating Scale (NRS) is a widely used instrument for the subjective assessment of pain intensity. It consists of a numerical scale from 0 to 10, where 0 indicates no pain and 10 represents the highest intensity. Patients select the number that best reflects the severity of their symptom.
Time frame: Pre- intervention, post- intervention (6 weeks) and follow-up of 8 weeks after the end
Pressure Pain Threshold (PPT)
The tip of the algometer will be applied perpendicularly to the muscle (anterior portion of the temporalis muscle and the superficial belly of the masseter muscle), and pressure will be gradually increased at a rate of 1 kg/sec. Participants will be instructed to signal the moment they first perceive pain, in order to accurately record the pressure pain threshold.
Time frame: Pre- intervention, post- interventio (6 weeks) and follow-up of 8 weeks after the end.
Maximum Pain-Free Mouth Opening (MPMO)
MPMO is a clinical measure used to assess mandibular function in patients with temporomandibular disorders (TMD). This variable evaluates the ability to open the mouth without experiencing pain, reflecting the functional status of the temporomandibular joint and the associated musculoskeletal structures.
Time frame: Pre- intervention, post- intervention (6 weeks) and follow-up of 8 weeks after the end.
Treatment Adherence
A personalized diary will be provided for each participant in both groups. Each program will include an exercise log that patients will be required to complete.
Time frame: Post- intervention (6 weeks)
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Aug 2025; primary completion for Oct 2025, 2 months later.
Of 242 non-industry interventional studies with no phase under Temporomandibular Joint Disorders, half reached primary completion within 11 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 21. This study's planned 2 months is below that.
Counting every sponsor, half of 246 studies reached it within 10 months; a quarter within 5 and three quarters within 21.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.
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Temporomandibular Joint Disorders →
University of Jaén