An interventional study of SRP+ANB+SURG and SRP+SURG in Periodontitis and Periodontal Diseases, sponsored by Medical University of Bialystok. Active, not recruiting at 1 site in Poland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-06-18.
Sponsored by Medical University of Bialystok · Not applicable, Interventional, and Treatment
Assessmnet of the influence of local antibiotic therapy on the clinical, radiological, microbiological parameters and the inflammation mediators levels in the gingival crevicular fluid (GCF) following periodontal regeneration procedures in patients with periodontitis.
Forty generally healthy adults diagnosed with stage III periodontitis were randomly divided into two groups. In the test group, SRP was performed with the subsequent application of local antibiotics (10% doxycycline) into periodontal pockets at the site of the planned surgical intervention, while in the control group SRP was performed alone. Two weeks after, on the day of the surgical treatment, the M-MIST/MIST procedure was performed in both the test and control groups with the use of enamel matrix derivative (EMD). Clinical examination was performed before and 6 and 12 months after treatment. For radiological measurements RVG was performed. For inflammation mediators levels determination in GCF samples ELISA method will be used. For microbiological assessments Real Time PCR method will be used.
1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.
This study's enrollment of 40 is below the median of 45 across 1,191 interventional studies indexed under Periodontitis.
Browse Periodontitis studies →Medical University of Bialystok is the lead sponsor of 68 studies on the registry; 17 are open to participants now.
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-presence of an intrabony defect, with a pocket depth (PD) ≥ 6 mm and a radiological defect depth of ≥3 mm and width of ≥2 mm;
Exclusion Criteria:
In the control group (20 subjects) SRP was performed alone. After two weeks regeneration procedure was performed.
Procedure: SRP+SURG
The test group consisted of 20 people participants who underwent the SRP procedure with local antibiotic application into the pocket was performed. After two weeks regeneration procedure was performed.
Drug: SRP+ANB+SURG
SRP (scaling and root planing) with ANB (local antibiotic application- 10%doxycycline) and SURG (regeneration procedure according to MIST/M-MIST)
SRP (scaling and root planing) and SURG (regeneration procedure according to MIST/M-MIST)
Assessment of the influence of local antibiotic therapy on the clinical, outcomes following periodontal regeneration procedures.
PD (Pocket Depth) reduction- measured from the gingival margin to the bottom of the sulcus (mm) CAL (Clinical Attachment Level) gain- measured from the cemento-enamel junction to the bottom of the sulcus (mm)
Time frame: up to 12 months after treatment procedure
Assessment of the influence of local antibiotic therapy on the radiological outcomes following periodontal regeneration procedures.
RIDW- (radiological intrabony defect width)- measured from bone crest to the root surface (mm) RIDD - (radiologial intrabony defect depth) - measured from bone crest to the bottom of the defect (mm)
Time frame: up to 12 months after treatment procedure
Plan to share: No — IPD cannot be transferred to other people due to GDPR
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This study is active, not recruiting, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.
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Medical University of Bialystok