An interventional study of Oxygen and medical air in Chronic Obstructive Pulmonary Disease (COPD), sponsored by George Papanicolaou Hospital. Active, not recruiting at 1 site in Greece. Per ClinicalTrials.gov, last updated 2025-06-17.
Sponsored by George Papanicolaou Hospital · Not applicable, Interventional, and Treatment
It is a randomised, single-blind trial of the effect of acute oxygen supplementation on cerebral oxygenation during the 30 sec Sit-To-Stand Test (STST) in chronic obstructive pulmonary disease patients, without resting hypoxemia. After an initial clinical assessment, patients preform the 30sec STST under near-infrared spectroscopy, a non invasive technique which assesses cerebral oxygenation at the prefrontal lobe. Measurements are performed twice, under oxygen supplementation or medical air, in a random order, and the patients are be blinded to the treatment (oxygen or medical air) given.
2,592 studies on the registry are indexed under Lung Diseases, Obstructive; 198 are open to participants now.
This study's planned enrollment of 25 is below the median of 66 across 1,837 interventional studies indexed under Lung Diseases, Obstructive.
Browse Lung Diseases, Obstructive studies →George Papanicolaou Hospital is the lead sponsor of 14 studies on the registry; 2 are open to participants now.
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Exclusion Criteria:
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Oxygen supplementation via nasal cannula at a rate of 3 lit/min
Drug: Oxygen
Medical air supplementation via nasal cannula at a rate of 3 lit/min
Drug: medical air
Oxygen supplementation via nasal cannula at a rate of 3 lit/min during 30sec Sit-To-Stand Test among COPD patients without resting hypoxemia
Medical Air supplementation via nasal cannula at a rate of 3 lit/min during 30sec Sit-To-Stand Test among COPD patients without resting hypoxemia
cerebral oxygenation at the prefrontal lobe
Near infrared spectroscopy will be utilised to assess cerebral oxygenation, by measuring oxygenated hemoglobin (O2Hb) at the prefrontal lobe, in COPD patients
Time frame: For 2 and a half minutes (one minute of rest, 30 seconds during Sit-To-Stand Test and one minute of recovery after the test)
Number of repetitions during Sit-To-Stand Test
The number of repetitions (fully standing and sitting) during the Sit-To-Stand Test
Time frame: From the initiation till the end of the Sit-To-Stand Test, that is 30 seconds.
Severity of dyspnea
Rate of dyspnea according to dyspnea Borg scale (0-10)
Time frame: At the end of the 30 second Sit-To-Stand Test
Severity of fatigue
Score according to Rate of Perceived Exertion
Time frame: At the end of the 30 seconds Sit-To-Stand Test
Plan to share: Undecided
This study is active, not recruiting, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.
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George Papanicolaou Hospital