An interventional study of Tele-Yoga Training in Postoperative Period and Lung Cancer (Diagnosis), sponsored by Istanbul University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-10-21.
Sponsored by Istanbul University · Not applicable, Interventional, and Treatment
Among 114 studies in Lung Neoplasms with a site in Turkey — 27 open to participants now, 45 under way, 19 of them phase 3. Lung Neoplasms · Turkey.
Among the 114 studies in Lung Neoplasms with a site in Turkey, this one is the 73rd largest by enrollment of the 87 interventional ones, is one of 18 that started in 2025, is one of 35 with no phase, and was the 90th registered.
5,422 studies on the registry are indexed under Lung Neoplasms; 1,346 are open to participants now.
This study's enrollment of 40 is below the median of 60 across 3,656 interventional studies indexed under Lung Neoplasms.
Browse Lung Neoplasms studies →27 of the 114 studies in Lung Neoplasms with a site in Turkey are open now, in 12 countries. Each count lists the studies.
Of the 996 Lung Neoplasms studies recruiting now, 683 (69%) set no upper age limit and 142 (14%) stop at 75 or younger; 45 take children under 18; 142 take healthy volunteers.
This study: 18 Years to 65 Years · all sexes · no healthy volunteers.
The full table on the hub →114 studies; the count open now beside each. This study's row is marked.
First in 1999; this study’s year is marked. 18 started in 2025.
Median enrollment 100 across the 87 interventional studies, 103 across the 26 observational. Of the 64 that completed or were terminated, 14 (22%) have results posted.
53 of 114 have an industry lead sponsor. The 10 most frequent:
Istanbul University is the lead sponsor of 511 studies on the registry; 78 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 1 (20%) have results posted.
Istanbul University has 3 studies filed under Lung Neoplasms — fewer than ten, so there is no comparison to draw.
12 of the studies in Lung Neoplasms with a site in Turkey that are under way reach primary completion within a year, 6 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07162883Phase 3Qilu Pharmaceutical Co., Ltd.Pharmacokinetic Study of QL2107 Versus Keytruda® for Adjuvant Therapy of Non-Small Cell Lung Cancer (NSCLC) | 2026-12-31 |
| NCT04380636Phase 3Merck Sharp & Dohme LLCStudy of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012) | 2027-05-05 |
| NCT05920356Phase 3AmgenA Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202) | 2027-06-30 |
| NCT06635824Phase 3GenmabTrial to Evaluate Acasunlimab and Pembrolizumab Combination Superiority Over Standard of Care Docetaxel in Non-Small Cell Lung Cancer (ABBIL1TY NSCLC-06) | 2027-07-30 |
| NCT06119581Phase 3Eli Lilly and CompanyA Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer | 2027-11 |
Among the 114 studies in Lung Neoplasms with a site in Turkey, from their registry updates:
This randomized controlled clinical trial aims to evaluate the effects of an 8-week tele-yoga intervention in individuals with lung cancer who have undergone lung resection surgery. The intervention group will receive supervised yoga sessions via online synchronous video conferencing, while the control group will continue with standard post-operative care. The primary outcome is exercise capacity (6-minute walk test), with secondary outcomes including pulmonary function, respiratory and peripheral muscle strength, physical activity level, dyspnea, fatigue, sleep quality, anxiety and depression, and quality of life. It is hypothesized that tele-yoga will improve physical and psychological recovery post-surgery and may serve as a feasible home-based pulmonary rehabilitation alternative.
Lung carcinoma, also referred to as pulmonary carcinoma, is a malignant tumor characterized by uncontrolled cell proliferation in the lung tissue, originating from epithelial cells. It is the most commonly diagnosed cancer type globally. Histopathologically, lung cancer is classified into two main categories: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). NSCLC constitutes approximately 85% of all lung cancer cases and is associated with high morbidity and mortality. According to the Tumor-Node-Metastasis (TNM) staging system developed by the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC), NSCLC is staged from I to IV. While SCLC has a lower prognostic value within the TNM system and is rarely operable, NSCLC is typically treated surgically in early stages.
Surgical treatment for early state of lung cancer includes lobectomy, pneumonectomy, segmentectomy, or wedge resection, depending on tumor location, lung function, and disease stage. The most commonly employed surgical approaches are thoracotomy, video-assisted thoracoscopic surgery (VATS), and robot-assisted thoracoscopic surgery (RATS). Although techniques such as VATS are associated with less postoperative pain, faster recovery, and better preservation of pulmonary function compared to thoracotomy, surgery still significantly reduces exercise capacity and contributes to long-term physical and psychological limitations.
Following lung resection, patients often experience a decline in exercise capacity, attributed to loss of lung parenchyma, ventilatory limitations, increased cardiac workload, thoracic pain, and muscle weakness. Dyspnea is prevalent in up to 60% of postoperative patients, many of whom did not experience dyspnea prior to surgery. Additionally, adjuvant chemotherapy and/or radiotherapy may cause pulmonary inflammation and fibrosis, further reducing lung function and quality of life. Sleep disturbances and psychological disorders such as anxiety and depression are also common during this period.
Exercise training is a non-pharmacological intervention that improves immune function and quality of life in cancer patients; however, traditional pulmonary rehabilitation programs are often underutilized postoperatively. There is increasing interest in mind-body exercise (MBE) modalities such as yoga, tai chi, and qigong, which integrate physical postures, breath control, and meditation. Among these, yoga has shown potential to improve exercise capacity, pulmonary function, muscle strength, fatigue, anxiety, depression, and sleep quality. Despite promising findings, there is a lack of evidence regarding the efficacy of structured yoga interventions specifically tailored for lung cancer patients post-surgery.
Furthermore, the transition from hospital to home poses challenges in ensuring the continuity and accessibility of rehabilitation services. Telehealth, defined as the provision of healthcare services via digital communication technologies, has emerged as a feasible platform for delivering home-based interventions. Tele-yoga, a form of remote supervised yoga practice, has shown benefits in various populations, including those with chronic obstructive pulmonary disease (COPD), heart failure, sleep apnea, and ankylosing spondylitis. However, no study has yet examined its application in post-surgical lung cancer patients.
Based on this gap in the literature, the present study aims to investigate the effects of an 8-week synchronized tele-yoga intervention on exercise capacity, pulmonary function, respiratory and peripheral muscle strength, physical activity level, dyspnea, fatigue, sleep quality, anxiety, depression, and health-related quality of life in patients who have undergone lung resection surgery for lung cancer. This will be the first randomized controlled trial to assess a comprehensive yoga-based telerehabilitation approach in this population. The findings may provide a cost-effective and practical home-based rehabilitation strategy to enhance physical and psychological recovery in lung cancer survivors.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The diagnosis was confirmed by looking at a sample under a microscope: tissue from a biopsy or surgery (histology), or cells from a fluid or needle sample (cytology).
Your pathology report is the document that shows this.
The study doctor’s estimate of how long someone is likely to live. Criteria use it so that people can stay in the study long enough for it to answer its question.
A 0–100 scale of how well someone can carry out everyday activities. 100 is no complaints and no signs of illness; 70 is able to look after yourself but not to work or keep up normal activity; 50 is needing considerable help and frequent medical care.
Studies often ask for 60 or 70 and above. Your doctor gives the score.
Histologically or cytologically confirmed
The diagnosis was confirmed by looking at a sample under a microscope: tissue from a biopsy or surgery (histology), or cells from a fluid or needle sample (cytology).
Your pathology report is the document that shows this.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Life expectancy
The study doctor’s estimate of how long someone is likely to live. Criteria use it so that people can stay in the study long enough for it to answer its question.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Karnofsky performance status (KPS)
A 0–100 scale of how well someone can carry out everyday activities. 100 is no complaints and no signs of illness; 70 is able to look after yourself but not to work or keep up normal activity; 50 is needing considerable help and frequent medical care.
Studies often ask for 60 or 70 and above. Your doctor gives the score.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants in this arm will receive an 8-week supervised tele-yoga program delivered via real-time video conferencing.
Other: Tele-Yoga Training
The control group continued to receive standard postoperative care without any additional exercise intervention.
The Tele-yoga group will participate in real-time yoga sessions three times a week for eight weeks, including individual sessions for the first two weeks and small group sessions for the remaining six weeks, with all sessions supervised by a certified instructor. Each session will last approximately 45-60 minutes and include a 5-10 minute warm-up, 15-20 minutes of yoga postures, 15-20 minutes of yogic breathing exercises, and 5-10 minutes of relaxation and meditation.
The Six-Minute Walk Test (6MWT)
Distance walked in six minutes will be recorded. Test will be conducted according to the guideline of American Thoracic Society. Functional exercise capacity will be evaluated with the six-minute walk test. Patients will be walked in a 30-meter-long corridor for 6 minutes and the maximum walking distance will be measured. Before and after the test, heart rate, blood pressure and O2 saturation will be measured with pulse oximetry, and dyspnea and fatigue levels will be determined according to the Modified Borg scale.
Time frame: Change from Baseline at 8 weeks
Incremental Shuttle Walk Test (ISWT)
The Incremental Shuttle Walk Test (ISWT) The Incremental Shuttle Walk Test adapted for chronic obstructive pulmonary disease (COPD) patients consists of 12 levels with progressively increasing walking speeds over a 10-meter course. The participant walks between two cones in response to auditory beeps from a laptop. The test continues until the participant is unable to maintain the required pace due to breathlessness or fatigue. The number of shuttles completed and total distance walked are recorded. VO₂max is calculated using the formula: VO₂max (ml/min/kg) = 4.19 + (0.025 × distance).
Time frame: Change from Baseline at 8 weeks
6-Minute Pegboard and Ring Test (6PBRT)
The 6PBRT evaluates upper extremity functional capacity by requiring participants to transfer rings from lower to upper pegs and back for 6 minutes. Participants may rest as needed, and the score is the total number of rings moved.
Time frame: Change from Baseline at 8 weeks
Pulmonary Function Tests (PFT)
Pulmonary function tests will be conducted using a portable spirometer, following the American Thoracic Society (ATS)/European Respiratory Society (ERS) criteria.
Time frame: Change from Baseline at 8 weeks
Respiratory Muscle Strength Test (MIP/MEP)
Using a portable electronic oral pressure measurement device, maximal inspiratory pressure (MIP) and expiratory pressure (MEP) are measured per ATS/ERS recommendations. The highest value from three reproducible efforts is recorded in centimetres of water (cmH2O) and as a percentage of the expected value.
Time frame: Change from Baseline at 8 weeks
Peripheral Muscle Strength (Handgrip Strength Test)
Handgrip strength is measured using a dynamometer. Participants perform three trials with each hand, and the highest score is recorded in kg.
Time frame: Change from Baseline at 8 weeks
Physical Activity Level (IPAQ-SF)
Physical activity level is assessed using the Turkish-validated version of the International Physical Activity Questionnaire - Short Form (IPAQ-SF). This self-reported questionnaire evaluates physical activity performed in the last 7 days across different intensity levels (walking, moderate, and vigorous activity). Results are expressed in Metabolic Equivalent of Task (MET)-minutes/week. Scores range from 0 to an open-ended maximum depending on the amount and intensity of physical activity reported. Higher scores indicate a better outcome, reflecting a higher level of physical activity.
Time frame: Change from Baseline at 8 weeks
Dyspnea Assessment (Cancer Dyspnea Scale - CDS)
Dyspnea severity is measured using the validated Turkish version of the Cancer Dyspnea Scale (CDS). This self-reported scale evaluates dyspnea in cancer patients through three subscales: effort, discomfort, and anxiety related to breathing. The total CDS score ranges from 0 to 27, with each subscale consisting of items rated on a 4-point Likert scale (0-3). Higher scores indicate worse outcomes, reflecting greater severity of dyspnea and its associated components.
Time frame: Change from Baseline at 8 weeks
Fatigue Assessment (Fatigue Severity Scale - FSS)
Fatigue is assessed using the 9-item Fatigue Severity Scale, scored on a 7-point Likert scale. A mean score ≥4 indicates severe fatigue.
Time frame: Change from Baseline at 8 weeks
Sleep Quality (Pittsburgh Sleep Quality Index - PSQI)
Sleep quality is measured using the Pittsburgh Sleep Quality Index (PSQI), a validated self-reported questionnaire that assesses sleep quality over the past month. It includes seven components: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medication, and daytime dysfunction. The total PSQI score ranges from 0 to 21. Higher scores indicate worse sleep quality, with a score greater than 5 suggesting poor sleep quality.
Time frame: Change from Baseline at 8 weeks
Anxiety and Depression (Hospital Anxiety and Depression Scale - HADS)
Anxiety and depression are assessed using the HADS, with subscale cutoff scores of 10 for anxiety and 7 for depression.
Time frame: Change from Baseline at 8 weeks
Quality of Life (European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30):
Cancer-specific quality of life is assessed using the validated Turkish version of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 (EORTC QLQ-C30). This instrument includes functional subscales (physical, role, emotional, cognitive, and social functioning), symptom subscales (e.g., fatigue, pain, nausea/vomiting), and a global health status/quality of life scale. Each item is scored on a Likert-type scale, and scores are linearly transformed to a 0-100 scale according to the EORTC scoring manual. For functional and global health status subscales, higher scores indicate better quality of life. For symptom subscales, higher scores indicate worse symptom burden.
Time frame: Change from Baseline at 8 weeks
Verbal Feedback
At the end of the 8-week intervention, participants in the intervention group will be asked to provide verbal feedback regarding safety, satisfaction, challenging poses, pros and cons of online sessions, and perceived effects of yoga.
Time frame: Post-intervention (Week 8)
Plan to share: No
No publications or documents are linked to this record.
Ran from Jun 2025 to primary completion in Sep 2026, 15 months.
Of 864 non-industry interventional studies with no phase under Lung Neoplasms, half reached primary completion within 35 months of starting (the median), counting those still running; a quarter within 16 and three quarters within 68. This study's 15 months is below that.
Counting every sponsor, half of 915 studies reached it within 34 months; a quarter within 15 and three quarters within 67.
Completion moved once since we started tracking on Sep 25, 2026: Oct 2026 → Sep 2026, on Oct 21, 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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