An interventional study of experimental group in Patellofemoral Pain Syndrome, sponsored by Cairo University. Completed at 1 site in Egypt. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2025-07-28.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
Patellofemoral pain syndrome (PFPS) is condition characterized by anterior knee pain that predominantly affects young and physically active females. The etiology of PFPS is multifactorial, involving biomechanical, muscular, and neuromuscular factors that contribute to altered patellar tracking and increased pain sensitivity.
This study will employ a randomized controlled trial (RCT) design to evaluate the effects of a targeted 8-week exercise program on pain measures and isokinetic muscle strength in females with PFPS. Thirty female patients diagnosed with PFPS will be recruited based on predefined inclusion and exclusion criteria. Participants will be randomly assigned into two groups: an intervention group receiving the targeted exercise program, and a control group will not receive any intervention.The intervention group will undergo a supervised, structured exercise program lasting 8 weeks, focusing on strengthening the hip and knee muscles, improving neuromuscular control, and addressing pain sensitivity. Sessions will be conducted multiple times per week under professional supervision. Outcome measures will include pain measures, assessed through validated tools such as pressure pain threshold and pain intensity measured by VAS scale and isokinetic muscle strength of knee and hip muscles, measured by isokinetic dynamometry at the Biodex isokinetic Laboratory at the Faculty of Physical Therapy, Cairo University.
295 studies on the registry are indexed under Patellofemoral Pain Syndrome; 75 are open to participants now.
This study's enrollment of 30 is below the median of 45 across 242 interventional studies indexed under Patellofemoral Pain Syndrome.
Browse Patellofemoral Pain Syndrome studies →Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.
Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
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Eligible participants will present with clinically diagnosed anterior knee pain exacerbated by activities such as stair climbing, squatting, or prolonged sitting, with a pain duration of at least three months to ensure chronicity. All participants will possess adequate intellectual and cognitive abilities to comprehend and follow exercise instructions, and they will provide informed consent prior to enrollment.
Exclusion Criteria:
Exclusion criteria will include any history of knee surgery or trauma within the past year, presence of other knee pathologies such as ligament injuries or osteoarthritis, neurological or systemic disorders affecting lower limb function, pregnancy, contraindications to exercise, or current involvement in other physical therapy or structured exercise programs targeting the knee.
patients receive specific weight bearing program known as weight bearing exercise for better balance program
Other: experimental group
patient will not receive any intervention
eight weeks of targeted weight bearing program
Also known as: weight bearing program
pain intensity
measured by Visual Analogue Scale. a score range from 0 to 10. 0 means no pain and 10 means severe pain
Time frame: two times of testing (before and 8 weeks after intervention)
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2025. You cannot join it, but the record below documents what was studied.
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Cairo University