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CompletedNCT06990607EndopthalmitisUpdated May 25, 2025

Compare PPV With and Without Silicone Oil in Managing Postoperative Endophthalmitis

An interventional study of Pars plana Vitrectomy and Silicone Oil in Endophthalmitis Following Cataract Surgery, sponsored by Benha University. Completed at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-05-25.

Sponsored by Benha University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 1 year 3 months after the study started (first participant enrolled Jan 2024, registered May 2025).
Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

Comparing PPV with and without silicone oil in managing postoperative endophthalmitis

Read the detailed description

The objective of this study is to compare the outcomes of PPV with silicone oil tamponade to PPV alone in patients with postoperative endophthalmitis by assessing visual acuity, and postoperative complications such as rhegmatogenous retinal detachment (RRD).

02

Conditions studied

  • Endophthalmitis Following Cataract Surgery

Keywords

  • Postoperative endophthalmitis
  • pars plana vitrectomy
  • silicone oil
03

In context

Endophthalmitis

55 studies on the registry are indexed under Endophthalmitis; 8 are open to participants now.

This study's enrollment of 40 is below the median of 113 across 32 interventional studies indexed under Endophthalmitis.

Browse Endophthalmitis studies →

Lead sponsor

Benha University is the lead sponsor of 356 studies on the registry; 68 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • adult patients (≥ 18 years) presenting with clinical manifestations of endophthalmitis after cataract surgery

Exclusion criteria

Exclusion Criteria:

  • patients with concurrent ocular or systemic conditions that could potentially confound study outcomes, such as active retinal diseases unrelated to endophthalmitis
  • pre-existing poor visual prognosis due to conditions like advanced glaucoma or macular degeneration, or prior ocular surgery affecting the study
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
40 participants (actual)

Study arms

  • Active comparator
    Group I

    Pars plana Vitrectomy Alone

    Procedure: Pars plana Vitrectomy

  • Active comparator
    Group II

    Pars plana Vitrectomy with Silicone Oil

    Procedure: Pars plana Vitrectomy · Procedure: Silicone Oil

Interventions

  • ProcedurePars plana Vitrectomy

    Pars plana Vitrectomy using 23 Gauge

  • ProcedureSilicone Oil

    Silicone Oil injection after PPV

06

What researchers measure

Primary outcomes

  1. visual acuity, with best-corrected visual acuity (BCVA) recorded using LogMAR

    log-MAR value (log of the minimum angle of resolution). Normal visual acuity for most adults is approximately -0.1 on this scale, which is equivalent to 20/16 on a Snellen visual acuity chart.

    Time frame: 1, 2, 4, and 12 weeks postoperatively

07

Study locations

1 site
  • Al-Azhar University
    Cairo, Egypt
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 25, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06990607
Lead sponsor
Benha University
Responsible party
Ehab Mohamed Elsayed Mohamed Saad (Lecturer, Benha University) — Principal investigator
First posted
May 25, 2025
Start date
Jan 20, 2024
Primary completion
Dec 1, 2024
Completion
Dec 1, 2024
Last update
May 25, 2025

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2025. You cannot join it, but the record below documents what was studied.

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