An observational study in Uveitis, Aqueous Humor and Infection, sponsored by Moorfields Eye Hospital NHS Foundation Trust. Recruiting at 1 site in United Kingdom. Per ClinicalTrials.gov, last updated 2026-07-21.
Sponsored by Moorfields Eye Hospital NHS Foundation Trust · Observational
The aim of this study is to apply a diagnostic test called 'metagenomic sequencing' to identify the involvement of potential infections in patients with ocular inflammation, where this hasn't been detected by currently available standard testing. For many people with ocular inflammation, no cause is ever found for their disease. In some cases, an infection or infectious trigger is suspected, but currently available tests are inadequate. Metagenomic sequencing can identify almost every globally known infection (bacteria, virus, fungi, parasites) in a sample. Therefore, it has the potential to identify an infection that has caused or triggered ocular inflammation, and as a consequence may help to identify specific treatments. It has the potential to improve our understanding of how to diagnose and treat people with this problem. This study will allow us to test the technique that has been previously optimised for brain infections, on ocular fluids. Participants will be 18 years of age or over and have active ocular inflammation which is suspected to be due to an infection, or an autoimmune process which has been triggered by an infection, but identification of this infection has not been possible using the investigations available as part of standard NHS care. Participants will be identified by the treating clinical team as requiring a sample of fluid from inside of the eye, and some of this fluid will be sent for metagenomic sequencing alongside standard testing. This study will be conducted at Moorfields Eye Hospital, London and will last for approximately a year. Participants will undergo additional non-invasive ocular imaging on the day of their clinic visit, but will not have to attend any additional research visits.
299 studies on the registry are indexed under Uveitis; 32 are open to participants now.
This study's planned enrollment of 36 is below the median of 107 across 104 observational studies indexed under Uveitis.
Browse Uveitis studies →Moorfields Eye Hospital NHS Foundation Trust is the lead sponsor of 48 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients in the UK attending Moorfields Eye Hospital, London.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients with Ocular Inflammation undergoing Metagenomics on Aqueous Humour
Diagnostic Test: Metagenomic sequencing of aqueous humor · Diagnostic Test: Ocular Imaging
Metagenomic Sequencing on aqueous humor surplus to diagnostic requirements
Ocular imaging with anterior segment OCT, laser flare photometry, confocal microscopy and colour fundus photography.
The percentage of participants who receive a clinically viable result from metagenomic sequencing
Time frame: 12 months
The number of patients who receive a result that leads to a change in treatment and beneficial outcome from metagenomic sequencing
Time frame: 12 months
Plan to share: Yes — Individual participant demographics and research findings will be shared in the peer-reviewed scientific publication.
Supporting information: Study protocol
Time frame: Within 12 months of study completion, for 5 years held in the Clinical Research Facility at Moorfields Eye Hospital.
Access criteria: On request to Moorfields Eye Hospital
Data sharing details ↗ · www.moorfields.nhs.uk
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Moorfields Eye Hospital NHS Foundation Trust