An observational study in Conjunctivitis and EBV Infection, sponsored by Moorfields Eye Hospital NHS Foundation Trust. Enrolling by invitation at 1 site in United Kingdom. Open to participants aged 16 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-11-14.
Sponsored by Moorfields Eye Hospital NHS Foundation Trust · Observational
Conjunctivitis means inflammation of the conjunctiva, the thin transparent layer over the white of the eye and under the eyelids. Acute conjunctivitis caused by infection is the most common condition seen in ophthalmic emergency departments, accounting for up to 10% of cases. It is responsible for 41% of eye-related general practice consultations. A diagnosis is usually made on the patient's symptoms and signs, despite this being less reliable than laboratory testing. When a cause is found, it is usually a common cold virus called adenovirus, that gets better with time and does not require treatment.
Through investigating cases of conjunctivitis at Moorfields, it has been discovered that in addition to adenovirus, Epstein Barr virus (EBV) is sometimes detected in conjunctival swabs from individuals with conjunctivitis. EBV is a very common viral infection that 95% of adults have experienced. EBV infection mostly passes unnoticed but when symptoms do occur, they include a sore throat, high temperature, swollen glands and tiredness, often called glandular fever or infectious mononucleosis. Conjunctivitis can also occur. EBV remains in the body after infection and rarely causes further problems. The virus can become active again occasionally, which is known as reactivation.
Reactivation usually passes unnoticed but sometimes is associated with recurrence of symptoms. It is possible that reactivation may cause conjunctivitis. It is not certain, which is will be observed as a part of this study, as it might be the cause of some of the conjunctivitis seen.
Through a collaboration with University College London (UCL), the aim is to gain further insight into infectious conjunctivitis, particularly in relation to EBV. This will be done by taking a swab of the conjunctiva, a single blood test and a tiny (1-2mm) tissue sample from the inner eyelid. Improved knowledge will allow the research team to develop better guidance and treatment for patients with conjunctivitis.
85 studies on the registry are indexed under Conjunctivitis; 5 are open to participants now.
This study's planned enrollment of 5 is below the median of 254 across 18 observational studies indexed under Conjunctivitis.
Browse Conjunctivitis studies →Moorfields Eye Hospital NHS Foundation Trust is the lead sponsor of 48 studies on the registry; 4 are open to participants now.
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Participants will be recruited from Moorfields A\&E. Eligible patients will be identified by a member of the clinical triage team. All eligible patients will be enrolled during the study period.
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Participants shall be considered eligible for inclusion if:
Exclusion Criteria:
Present with symptoms/signs such that another diagnosis is deemed more likely, for example topical medication-induced conjunctivitis.
The number of participants with clinically suspected viral conjunctivitis in which EBV DNA is identified on NAAT.
To confirm the proportion of: * participants with clinically suspected viral conjunctivitis in which EBV DNA is identified on NAAT. * EBV NAAT-positive participants who have a new EBV infection versus those with a reactivation of earlier disease. * participants in whom EBV is confirmed the cause of conjunctivitis on further investigation.
Time frame: From enrollment to the end of visit 2 which can occur within up to 7 days from enrollment.
Plan to share: No
No publications or documents are linked to this record.
Started Oct 2024 (actual). Primary completion is estimated for Jun 2025, 7 months after the start.
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Moorfields Eye Hospital NHS Foundation Trust