An interventional study of Vitrectomy and Intravitreal antibiotics in Endophthalmitis Postoperative Acute, sponsored by Moorfields Eye Hospital NHS Foundation Trust. Completed at 1 site in United Kingdom. Open to participants aged 18 Years to 95 Years. Per ClinicalTrials.gov, last updated 2025-07-03.
Sponsored by Moorfields Eye Hospital NHS Foundation Trust · Not applicable, Interventional, and Treatment
This randomised clinical trial will explore the feasibility and acceptability of carrying out early vitrectomy surgical treatment compared to standard treatment in acute endophthalmitis. We will investigate the effectiveness of early vitrectomy plus intravitreal antibiotics compared to standard care intravitreal antibiotic injections in the management of postoperative exogenous endophthalmitis. This is a feasibility trial that will evaluate the expected effect size with which to inform the design of a definitive randomized trial of this question.
The EVIAN Study is a multicentre, feasibility, randomised controlled trial to evaluate the effect of early vitrectomy surgery on acute endophthalmitis.
Patients with postoperative exogenous endophthalmitis following any ocular surgery/procedure/injection intervention will be recruited at 48 hours following initial presentation.
Patients with vision of 35 ETDRS letters or better are ineligible for the trial, and would continue on standard of care management. Patients with vision of worse than 35 ETDRS letters will be eligible for the study. At the 48-hour time-point, eligible patients will be randomised in a 1:1 ratio.
The treatment group will undergo vitrectomy within 48 hours of randomisation. The control group will have continued intravitreal antibiotic eye injections according to local protocols. If the vision reaches perception of light, then a vitrectomy surgery would be considered as part of standard of care at 12-15 days. Follow up will be for 6 months in both groups.
Visual acuity, funds photography, B-scan ultrasound, and optical coherence tomography (OCT) scanning will be performed from baseline until the final follow-up at 24 weeks.
Moorfields Eye Hospital NHS Foundation Trust is the lead sponsor of 48 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Vitrectomy surgery plus intravitreal antibiotics
Procedure: Vitrectomy · Procedure: Intravitreal antibiotics
Intravitreal antibiotics
Procedure: Intravitreal antibiotics
Vitrectomy within 48 hours of randomisation
Intravitreal Antibiotics at 48 hours
Patient recruitment
Number of participants
Time frame: Trial study period (Week 1 to Week 104)
Distance Best Corrected Visual Acuity change from baseline
Early Treatment Diabetic Retinopathy Study (ETDRS) letters
Time frame: Trial study period (Week 1 to Week 24)
Plan to share: Yes — Individual participant data that underlie the results to be reported in an International Committee of Medical Journal Editors journal after deidentification (text, tables, figures, and appendices)
Supporting information: Sap
This study is completed, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.
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Moorfields Eye Hospital NHS Foundation Trust