An observational study in Prevalence of Myocarditis in MINOCA Patients, sponsored by Assiut University. Not yet recruiting. Open to participants aged 17 Years to 80 Years. Per ClinicalTrials.gov, last updated 2025-05-12.
Sponsored by Assiut University · Observational
This study aims to determine the prevalence of myocarditis among patients suspected of having myocardial infarction with non-obstructive coronary arteries (MINOCA) and to analyze its clinical characteristics, diagnostic markers .
Acute myocardial infarction (AMI) remains the leading causes of high morbidity and mortality worldwide, Recently, a distinct population with myocardial infarction with nonobstructive coronary arteries (MINOCA) has been increasingly recognized because of the widespread use of coronary angiography. MINOCA occurs in 5%-10% of all AMI and they are younger and more often women compared to patients with AMI and obstructive coronary artery disease (CAD) , The underlying causes of MINOCA are manifold and may include plaque rupture or erosion, thromboembolism, coronary spasm, spontaneous dissection, microvascular dysfunction and supply/demand mismatch. Some non-ischemic diseases such as myocarditis may also mimic the presentation of MINOCA .Of note, several studies have found that the prognosis of MINOCA is not trivial and patients are still at considerable risks for long-term adverse cardiovascular (CV) events despite the optimal secondary prevention treatments [[6], [7], [8], [9], [10]]. Thus, it is of necessity and profound implications to find potential residual risk factors and improve prognosis in MINOCA population.
Myocarditis is commonly caused by viral infections, but it can also be caused by bacterial infections, toxic substances, or autoimmune disorders . Myocarditis is more common in younger patients, although it affects patients of all ages. Fulminant myocarditis, although rare, can result in life-threatening cardiogenic shock . Diagnosis of myocarditis is made using CMRI characterized by the presence of diffuse myocardial edema on T2 and with myocardial biopsy . In a meta-analysis of five observational studies with available CMRI data, one-third of MINOCA patients had myocarditis. It was more common in younger patients and those with high C-reactive protein .
174 studies on the registry are indexed under Myocarditis; 75 are open to participants now.
This study's planned enrollment of 148 is below the median of 208 across 120 observational studies indexed under Myocarditis.
Browse Myocarditis studies →Assiut University is the lead sponsor of 5,078 studies on the registry; 2,178 are open to participants now.
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Study Population Description Myocardial infarction patients who were underwent PPCI and the coronary angiography showing insignificant lesions (stenosis less than 50% )
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Exclusion Criteria:
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A recording of the heart’s electrical activity, taken with stickers on the chest, arms and legs. It takes a few minutes and does not hurt.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
ECG (electrocardiogram)
A recording of the heart’s electrical activity, taken with stickers on the chest, arms and legs. It takes a few minutes and does not hurt.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
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Acute Myocardial infarction patient with non obstructive coronary arteries
Procedure: Coronary angiography
distinguish between true MI with significant lesion and MINOCA with insignificant lesions (less than 50%)
Prevalence of myocarditis in patients presenting with MINOCA, as diagnosed by CMR.
Studying The incidence of myocarditis in MINOCA patients
Time frame: 1 years
No study locations are listed for this record.
Plan to share: Undecided
Start is estimated for May 2025; primary completion for Mar 2027, 21 months later.
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This study is not yet recruiting, as verified in May 2025. You cannot join it, but the record below documents what was studied.
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