An observational study in Epilepsy With Partial Onset Seizures With or Without Secondary Generalization, Psychoses and Epilepsy, Generalized, sponsored by Central Hospital, Nancy, France. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-08-06.
Sponsored by Central Hospital, Nancy, France · Observational
Background :
Psychiatric comorbidities are common in epilepsy, affecting 50 to 70% of patients, especially when the epilepsy is focal and drug-resistant. Among these comorbidities, psychotic disorders (involving hallucinations and delusions) affect 8% of patients - that is, eight times more frequently than in the general population. Currently, the links between epilepsy and psychotic disorders are poorly understood and often overlooked by physicians, which impacts the mental health care of patients with epilepsy and leads to underdiagnosis.
The aim of this research is to determine whether there are differences in epileptic symptoms between patients with a psychotic comorbidity and those without.
Study design :
The main objective of this research is to better understand whether certain emotional epileptic symptoms are associated with a higher risk of developing psychotic symptoms.
The secondary objectives of this study are to investigate whether the level of consciousness during seizures is associated with a higher risk of developing psychotic symptoms.
To meet these objectives, the study will include patients who (1) have epilepsy, (2) were hospitalized in the video-EEG unit of the Neurology Department at Central Hospital for seizure recording, and (3) underwent a psychiatric evaluation in the context of epilepsy between January 1, 2016, and April 1, 2025.
The study will take place at the University Hospital Center (CHRU) of Nancy, in the Neurology Department, within the video-EEG unit led by Professor Louis Maillard. The research will involve comparing epileptic symptoms between the group of patients without psychosis and the group of patients with psychosis.
Data collection will cover the five days of video-EEG hospitalization, along with information from the psychiatric evaluation, for a total duration of approximately one week per year.
Information for participants:
As part of the routine medical care, data is collected in medical records to ensure appropriate follow-up. For the purposes of this research, data from the medical record will be collected.
No identifying information (such as name, initials, full date of birth, address, or social security number) will be collected.
No additional visits or examinations will be required. Patients will not be contacted or asked to provide any new information.
1,587 studies on the registry are indexed under Psychotic Disorders; 281 are open to participants now.
This study's enrollment of 117 is close to the median of 123 across 221 observational studies indexed under Psychotic Disorders.
Browse Psychotic Disorders studies →Central Hospital, Nancy, France is the lead sponsor of 798 studies on the registry; 186 are open to participants now.
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Patients with a certain diagnosis of epilepsy, based on a video-EEG monitoring, hospitalized in tertiary center for epilepsy care, and who have a psychiatric evaluation specialized in patients with epilepsy.
There are limited exclusion criteria to ensure the best representation of patients with epilepsy
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients diagnosed with epilepsy based on video-EEG recording of seizures and with a psychotic comorbidity according to a standardized psychiatric assessment specialized in Epi-Psy
Patients diagnosed with epilepsy based on video-EEG recording of seizures and without psychotic comorbidity according to a standardized psychiatric assessment specialized in Epi-Psy
Ictal emotions
Clinician-assessment of ictal affective symptomatology (facial, verbal, and motor expression), based on a the visualization of an usual seizure recorded in video-EEG.
Time frame: From april 2025 to may 2025
Ictal consciousness
Clinician-rating of the Consciousness Seizure Scale (CSS) validated for the assessment of level of consciousness during a seizure. Scores on the CSS range from 0 to 9, which can be interpreted as follows * 0 or 1 meaning a profound alteration of consciousness during seizure * 2 to 5 meaning an intermediate alteration of consciousness during seizure * 6 and more meaning a relatively preserved consciousness during seizure
Time frame: From april 2025 to may 2025
Ictal dysautonomy
Measures of neurovegetatives signs during seizures based on ictal EKG, nurse examination (palor, ...)
Time frame: From april 2025 to may 2025
Type of aura
Assessment of the type of aura based on the patients description of their seizure and on the video-EEG recording at the beginning of the seizure
Time frame: From april 2025 to may 2025
Plan to share: Undecided
This study is completed, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.
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