An interventional study of Aquatic Exercise and Land-Based Rehabilitation in Osteoarthritis, Knee and Obesity, sponsored by University of Sistan and Baluchestan. Enrolling by invitation at 1 site in Iran, Islamic Republic of. Open to male participants aged 45 Years to 65 Years. Per ClinicalTrials.gov, last updated 2025-04-27.
Sponsored by University of Sistan and Baluchestan · Not applicable, Interventional, and Treatment
This RCT evaluates whether WATERinMOTION aquatic therapy improves pain, function, and quality of life more effectively than land-based exercise in obese men with knee osteoarthritis (OA). We will assess clinical outcomes (WOMAC), serum biomarkers (COMP, IL-6), and real-world activity (accelerometry) at baseline, 8 weeks, and 6 months.
100 participants (BMI ≥30, age 45-65, radiographic knee OA) will be randomized to:
Aquatic group: 24 sessions over 8 weeks (3x/week) in 32°C water, progressing from buoyancy-assisted to resistance exercises.
Land group: Matched duration/intensity land-based rehabilitation. Primary outcomes: WOMAC pain/function. Secondary outcomes: SF-36 quality of life, serum COMP, 6-minute walk test, and accelerometer-measured step count.
4,398 studies on the registry are indexed under Osteoarthritis; 582 are open to participants now.
This study's planned enrollment of 100 is above the median of 70 across 3,440 interventional studies indexed under Osteoarthritis.
Browse Osteoarthritis studies →University of Sistan and Baluchestan is the lead sponsor of 7 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Supervised WATERinMOTION sessions (60 mins, 3x/week) in heated pool. Focus on progressive resistance and mobility exercises.
Behavioral: Aquatic Exercise
Matched frequency/duration land-based program emphasizing core stabilization and low-impact aerobics.
Behavioral: Land-Based Rehabilitation
Supervised WATERinMOTION sessions (60 mins, 3x/week) in heated pool. Focus on progressive resistance and mobility exercises.
Matched frequency/duration land-based program emphasizing core stabilization and low-impact aerobics.
WOMAC Pain Subscale
Change from baseline in WOMAC pain score (0-20 scale).
Time frame: Baseline, 8 weeks, 6 months
WOMAC Function Subscale
Change in functional disability (0-68 scale).
Time frame: Baseline, 8 weeks, 6 months
SF-36 Quality of Life
Physical/Mental Component Summaries (0-100).
Time frame: Baseline, 8 weeks, 6 months
Serum COMP
Change in cartilage oligomeric matrix protein (ng/mL).
Time frame: Baseline, 8 weeks
Daily Step Count
Measured via ActiGraph GT9X accelerometer.
Time frame: Continuous over 8 weeks
Plan to share: No — Privacy concerns (sensitive health data of overweight/obese men). Lack of pre-specified data-sharing plan in ethics approval.
No publications or documents are linked to this record.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
No contact was published for this record. The registry link below has the sponsor’s details.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Sistan and Baluchestan