A Phase 4 interventional study of ultra-high molecular weight hyaluronic acid injection and high molecular weight hyaluronic acid injection in Subdeltoid Bursitis of the Shoulder, sponsored by Shin Kong Wu Ho-Su Memorial Hospital. Not yet recruiting. Open to participants aged 20 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-30.
Sponsored by Shin Kong Wu Ho-Su Memorial Hospital · Phase 4, Interventional, and Treatment
The study employs a double-blind, randomized clinical trial design with 50 patients diagnosed with subdeltoid bursitis. Participants are divided into two groups: ultra-high-molecular-weight hyaluronic acid or high-molecular-weight hyaluronic acid injection. All injections are guided by ultrasound. Assessments are conducted before treatment and at 1 week, 1 month, and 3 months post-treatment.
Evaluation indicators include pain (measured by Visual Analog Scale), function (assessed by Disabilities of the Arm, Shoulder, and Hand score and Shoulder Pain and Disability Index), quality of life (using the World Health Organization Quality of Life-BREF).
10,054 studies on the registry are indexed under Pain; 1,649 are open to participants now.
This study's planned enrollment of 52 is below the median of 66 across 8,493 interventional studies indexed under Pain.
Browse Pain studies →Shin Kong Wu Ho-Su Memorial Hospital is the lead sponsor of 65 studies on the registry; 16 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Unilateral shoulder pain within the past 3 months
Pain during joint movements such as abduction or internal rotation
At least one positive result from the following tests: Painful arc, Neer test, or Hawkins test
No shoulder injections received in the past 3 months
Willingness to receive injection treatment and undergo follow-up assessments
Avoid use of anti-inflammatory painkillers during the study period as much as possible; if intolerable pain occurs, acetaminophen (provided by the researcher) will be used to relieve symptoms
Exclusion Criteria:
Presence of infectious disease, inflammation, rheumatoid arthritis, or fracture
History of
Previous shoulder surgery
Sensory deficits
Total tendon rupture of the rotator cuff or biceps tendon
Neurological disorders causing hand weakness or affecting shoulder mobility (e.g., stroke, Parkinson's disease, brachial plexus injury, peripheral neuropathy) Cognitive impairment preventing completion of questionnaires
Cervical radiculopathy
Diagnosed frozen shoulder (adhesive capsulitis)
Psychiatric disorders
Breastfeeding or pregnant women
Received shoulder injection within the past 3 months, including , hyaluronic acid, -rich plasma, or any prolotherapy solution
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Blood cells that help blood clot. Too few raises the risk of bleeding and bruising. A usual adult range is about 150–400 × 10⁹/L (150,000–400,000 per µL); each lab has its own reference range.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Platelets
Blood cells that help blood clot. Too few raises the risk of bleeding and bruising. A usual adult range is about 150–400 × 10⁹/L (150,000–400,000 per µL); each lab has its own reference range.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Drug: ultra-high molecular weight hyaluronic acid injection
Drug: high molecular weight hyaluronic acid injection
ultra-high molecular weight hyaluronic acid
Ultrasound-guided injection into subdeltoid bursa
Shoulder Pain and Disability Index
A questionnaire to evaluate the severity of shoulder pain and disability in patients with shoulder problems; higher scores indicated more significant pain and disability
Time frame: Score change from baseline to 1 week, 1 months and 3 months of treatment, higher score, the better outcome
Disabilities of the Arm, Shoulder, and Hand
The questionnaire measures physical function and symptoms in people with upper-limb disorders, including conditions affecting the shoulder, elbow, wrist, or hand. The score ranges from 0 to 100: 0 = no disability; 100 = most severe disability
Time frame: Score change from baseline to 1 week, 1 months and 3 months of treatment, higher score, the better outcome
Range of motions of shoulder joint
Range of motion of the shoulder joint
Time frame: Score change from baseline to 1 week, 1 months and 3 months of treatment, higher score, the better outcome
World Health Organization Quality of Life
Assesses 4 key domains: Physical Health, Psychological , Social Relationships and Environment, score ranges 0-100, higher score indicates greater health
Time frame: Score change from baseline to 1 week, 1 months and 3 months of treatment, higher score, the better outcome
visual analog scale
Measuring subjective pain intensity, score ranges from 0 to 10 (or 0 to 100 mm, depending on format), the higher score indicates more severe symptom
Time frame: Score change from baseline to 1 week, 1 months and 3 months of treatment, higher score, the better outcome
No study locations are listed for this record.
Plan to share: No — The data will be available upon request to the investigator
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Shin Kong Wu Ho-Su Memorial Hospital