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CompletedNCT06931353ADB and PODUpdated Apr 17, 2025

Effect of the Anticholinergic Drug Burden on Postoperative Delirium in Elderly Chinese Patients: A Nested Case-Control Study

An observational study in Delirium - Postoperative, sponsored by Hao Li. Completed at 1 site in China. Open to participants aged 65 Years to 90 Years. Per ClinicalTrials.gov, last updated 2025-04-17.

Sponsored by Hao Li · Observational

Study type
Observational
Model
Cohort
Time perspective
Cross-sectional
Enrollment
10,536
Ages
65 Years to 90 Years
Sex
All
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Study summary

This study aims to investigate the association between preoperative anticholinergic drugs burden and postoperative delirium in elderly Chinese patients.

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Conditions studied

  • Delirium - Postoperative
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In context

Delirium

1,057 studies on the registry are indexed under Delirium; 238 are open to participants now.

This study's enrollment of 10,536 is above the median of 200 across 418 observational studies indexed under Delirium.

Browse Delirium studies →

Lead sponsor

Hao Li is the lead sponsor of 4 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
65 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

patients over 65 years

Inclusion criteria

  • patients over 65 years; Undergoing general anesthesia; Inpatients who had surgery between Aprill 1, 2020 and Aprill 1, 2022.

Exclusion criteria

Exclusion Criteria:

  • ASA grade V; preoperative Mini-Mental State Examination (MMSE) score \<24;history of neurological disorders (such as cerebrovascular disease or dementia); emergency surgeries; operative duration ≤30 minutes, and cases with >5% missing data.
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Study design

Observational model
Cohort
Time perspective
Cross-sectional
Enrollment
10,536 participants (actual)
Target follow-up
1 Month
Patient registry
Yes
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What researchers measure

Primary outcomes

  1. postoperative delirium

    Time frame: 7 days after surgery

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Study locations

1 site
  • First Medical Center of Chinese PLA General Hospital
    Beijing, China
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 17, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06931353
Lead sponsor
Hao Li
Responsible party
Hao Li (associate chief physician, Chinese PLA General Hospital) — Sponsor-investigator
First posted
Apr 17, 2025
Start date
Apr 1, 2020
Primary completion
Apr 1, 2022
Completion
Apr 1, 2022
Last update
Apr 17, 2025

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.

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Discussion

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