An observational study in COPD, Interstitial Pneumonia and Bronchiectasis, sponsored by Zhejiang University. Not yet recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-04-22.
Sponsored by Zhejiang University · Observational
This study analyzes patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University from 2017 to 2024, focusing on anesthesia's impact on post-op results. It gathers patient data from hospital and Mediston systems, with main focus on in-hospital complications and secondary focus on ICU stay, post-op hospitalization, mortality, and intubation time. The research aims to deepen understanding of anesthetic management's role in lung transplant outcomes and guide improvements in perioperative anesthesia protocols.
5,520 studies on the registry are indexed under Pulmonary Disease, Chronic Obstructive; 856 are open to participants now.
This study's planned enrollment of 250 is above the median of 158 across 1,497 observational studies indexed under Pulmonary Disease, Chronic Obstructive.
Browse Pulmonary Disease, Chronic Obstructive studies →Zhejiang University is the lead sponsor of 356 studies on the registry; 166 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University between January 2017 and October 2024
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
In this group, we collected perioperative clinical data and analyzed risk factors associated with patient outcomes.
In-hospital adverse events
In-hospital adverse events were defined as post-transplant complications occurring prior to discharge, such as: Grade 3 PGD, respiratory infections, stroke, cardiac events, AKI, or liver impairment.
Time frame: Collect data for an expected average about 2 hours
ICU stay
The ICU stay （days） was calculated from the time of ICU admission after surgery completion to actual discharge from the intensive care unit
Time frame: Collect data for an expected average about 2 hours
Postoperative hospital stay
Postoperative hospital（days）stay after lung transplantation
Time frame: Collect data for an expected average about 2 hours
In-hospital mortality
The proportion of patients who died during the initial hospitalization period following lung transplantation surgery
Time frame: Collect data for an expected average about 2 hours
30-day postoperative mortality
Number of deaths within 30 days post-transplant) / (Total number of lung transplant recipients) × 100%；
Time frame: Collect data for an expected average about 2 hours
90-day postoperative mortality
Number of deaths within 90 days post-transplant) / (Total number of lung transplant recipients) × 100%
Time frame: Collect data for an expected average about 2 hours
The duration of endotracheal intubation
Duration of intubation should be recorded from surgery end-time to extubation
Time frame: Collect data for an expected average about 2 hours
Grade 3 Primary Graft Dysfunction (PGD)
PGD3:A ratio of arterial oxygen partial pressure to fraction of inspired oxygen (PaO₂/FiO₂) \< 200 mmHg with bilateral infiltrates on chest radiograph, or Requirement for extracorporeal life support (ECLS) within 72 hours postoperatively, or use of inhaled pulmonary vasodilators for \>48 hours during mechanical ventilation.
Time frame: Collect data for an expected average about 2 hours
Pulmonary Infection
Radiologically confirmed by a staff radiologist as new or progressive pulmonary infiltrates on: Chest X-ray or Computed tomography (CT) scan
Time frame: Collect data for an expected average about 2 hours
Acute Kidney Injury
A rise in serum creatinine \>120 μmol/L
Time frame: Collect data for an expected average about 2 hours
Cardiovascular Events
Acute myocardial infarction； heart failure；Cardiovascular hemorrhage；Clinically significant arrhythmias；Conduction system disorders；Cardiac arrest；Refractory hypotension due to cardiogenic sock.
Time frame: Collect data for an expected average about 2 hours
Hepatic Dysfunction
Aspartate aminotransferase (AST) \>34 or Alanine aminotransferase (ALT) \>40 U/L;
Time frame: Collect data for an expected average about 2 hours
Cerebral Infarction
Diagnosed by staff radiologists as new or progressive ischemic lesions on CT or MRI
Time frame: Collect data for an expected average about 2 hours
Plan to share: Undecided
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.
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Pulmonary Disease, Chronic Obstructive →