An interventional study of Yerba mate consumption (Ilex paraguayensis) A and Yerba mate comsuption (ilex paraguayencis) B in Lipid Metabolism Disorders, sponsored by Universidad Nacional de Caaguazu. Recruiting at 1 site in Paraguay. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-16.
Sponsored by Universidad Nacional de Caaguazu · Not applicable, Interventional, and Prevention
Introduction: This project studies the impact of Ilex paraguariensis harvest time, commonly known as yerba mate, and its consumption mode (mate, tereré, and mate/terere) on the lipid profile of consumers in the Department of Caaguazú, Paraguay. Yerba mate is rich in bioactive compounds such as polyphenols, xanthines, and saponins. There are no clinical trials conducted in Paraguay with our Ilex paraguariensis plantations that have analyzed the influence of harvest time on the yerba mate production process and the infusion mode, in relation to its effect on dyslipidemias. General Objective: To establish the effectiveness of Ilex paraguariensis harvest time and the mode of consumption of the produced yerba mate on the lipid profile of consumers in the Department of Caaguazú, Paraguay. Methodology: The research approach will be quantitative, using a triple-blind randomized clinical trial design. Participants will be regular consumers of yerba mate, divided into groups based on harvest time (beginning or end of the harvest) and consumption mode (mate, tereré, or both). Lipid profile measurements will be taken at baseline and at 30, 90, and 180 days after consumption. Yerba mate samples will be analyzed and classified according to their bioactive properties before being blinded to the researchers and participants. Expected results: a report on the social, cultural, and anthropometric characterization of regular consumers of mate and tereré, and a report on the concentrations of the bioactive properties of yerba mate; polyphenols, xanthines, saponins from Ilex paraguariensis harvested at the beginning and end of the harvest and the database of patients with baseline lipid profile results, at 30, 90, and 180 days of mate and tereré consumers with yerba mate prepared randomly according to the harvest time of the Ip (beginning or end of harvest) analyzed.
177 studies on the registry are indexed under Lipid Metabolism Disorders; 36 are open to participants now.
This study's planned enrollment of 198 is above the median of 60 across 129 interventional studies indexed under Lipid Metabolism Disorders.
Browse Lipid Metabolism Disorders studies →Universidad Nacional de Caaguazu is the lead sponsor of 5 studies on the registry; 2 are open to participants now.
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Exclusion Criteria:
Yerba consumption of mate only
Dietary Supplement: Yerba mate consumption (Ilex paraguayensis) A · Dietary Supplement: Yerba mate comsuption (ilex paraguayencis) B
Yerba mate terere consumption only
Dietary Supplement: Yerba mate consumption (Ilex paraguayensis) A · Dietary Supplement: Yerba mate comsuption (ilex paraguayencis) B
Yerba mate consuptiom as mate and terere
Dietary Supplement: Yerba mate consumption (Ilex paraguayensis) A · Dietary Supplement: Yerba mate comsuption (ilex paraguayencis) B
Yerba mate of the begining of the harvest time
Yerba mate of the final time of the harvest
Effect on lipid profile
Effect of total cholesterol, LDL, HDL and tryglicerids
Time frame: six months
Plan to share: Undecided — It could be shared with anonimous data for the participants
No publications or documents are linked to this record.
Started Feb 2026 (actual). Primary completion is estimated for Aug 2026, 6 months after the start.
Of 39 non-industry interventional studies with no phase under Lipid Metabolism Disorders, half reached primary completion within 15 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 71. This study's planned 6 months is below that.
Counting every sponsor, half of 46 studies reached it within 14 months; a quarter within 6 and three quarters within 31.
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Universidad Nacional de Caaguazu