A Phase 3 interventional study of HAL lenses for children with strabismus and SVL for children with strabismus in Myopia and Strabismus, sponsored by Singapore National Eye Centre. Not yet recruiting at 1 site in Singapore. Open to participants aged 5 Years to 12 Years. Per ClinicalTrials.gov, last updated 2025-03-07.
Sponsored by Singapore National Eye Centre · Phase 3, Interventional, and Treatment
Among 16 studies in Myopia by Singapore National Eye Centre — 5 open to participants now, 6 under way, 2 of them phase 3. Myopia · Singapore National Eye Centre.
Among the 16 studies in Myopia by Singapore National Eye Centre, this one is the 8th largest by planned enrollment of the 11 interventional ones that give a count, is one of 3 that started in 2025, is one of 2 in phase 3, and was the 14th registered.
1,159 studies on the registry are indexed under Myopia; 225 are open to participants now.
Browse Myopia studies →5 of the 16 studies in Myopia by Singapore National Eye Centre are open now, in 1 country. Recruiting first, the newest first:
Singapore National Eye Centre · Sites in Singapore
Singapore National Eye Centre · Sites in Singapore
Singapore National Eye Centre
Singapore National Eye Centre · Sites in Singapore
By country, each count listing its studies:
Of the 122 Myopia studies recruiting now, 19 (16%) set no upper age limit and 102 (84%) stop at 75 or younger; 86 take children under 18; 53 take healthy volunteers.
This study: 5 Years to 12 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
16 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 2 · Phase 2 2 · Phase 3 3
First in 2002; this study’s year is marked. 3 started in 2025.
This study's planned enrollment of 40 is below the median of 78 across 923 interventional studies indexed under Myopia.
Median enrollment 70 across the 11 interventional studies, 150 across the 2 observational. Of the 8 that completed or were terminated, 0 (0%) have results posted.
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Singapore National Eye Centre is the lead sponsor of 87 studies on the registry; 14 are open to participants now.
2 of the studies in Myopia by Singapore National Eye Centre that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06717035Singapore National Eye CentreEvaluation of Performance of MiYOSMART Photochromic and Clear Spectacle Lenses in Myopic Children | 2027-01-02 |
| NCT07779941Singapore National Eye CentreA Pilot Evaluation of Refractive Error Progression in Pre-Myopic Children in Singapore With and Without Myopia Control Spectacles | 2027-08 |
Among the 16 studies in Myopia by Singapore National Eye Centre, from their registry updates:
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Assess the effect and changes of eye misalignment (strabismus) with myopia control glasses Assess the efficacy of myopia control glasses on childhood myopia progression in children with strabismus due to the uncertainty clinicians face when prescribing myopia control glasses to these strabismic children
Studies have been done to show that spectacles, atropine eye drops, and outdoor activities have some efficacy in slowing myopia progression in children, however most of such studies exclude children with significant eye conditions such as strabismus or nystagmus to isolate the effects of myopia control treatment. In this study, we would like to investigate whether these specialized glasses can effectively slow down the progression of myopia in children with strabismus. Since strabismus can affect visual development, this study would also be able to assess the effect and changes of eye misalignment (strabismus) with myopia control glasses. The study also aims to assess the efficacy of myopia control glasses on childhood myopia progression in children with strabismus due to the uncertainty clinicians face when prescribing myopia control glasses to these strabismic children.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Age 5-12 years old Myopia of between -1D and -6D in at least 1 eye Progression of at least 0.5D within the last year Astigmatism less than 2.5D Exotropia Exophoria: horizontal deviation \<40PD Esotropia (good control), Esophoria: horizontal deviation \<40PD Any vertical strabismus: Vertical deviation \<10 PD Intermittent exotropia (good, moderate, poor) Horizontal deviation ≥15 PD, vertical deviation ≤5 PD (?)
Exclusion Criteria:
VA poorer than logMAR 0.2 (6/9.5) in either eye Any other ocular condition (e.g. lens opacity, glaucoma) other than myopia, strabismus or nystagmus) Any medical/neurological condition which would interfere with subjects ability to co-operate with tests and attend follow-up appointments.
Plans of surgery for strabismus or nystagmus in the next year Constant XT). Past use of any other from of myopia control treatment (eg. atropine or myopia control glasses or contact lenses) within the last year.
Stellest lenses for children with strabismus
Device: HAL lenses for children with strabismus
SVL for children with strabismus
Device: SVL for children with strabismus
It has been shown that peripheral segmented defocus spectacles can slow myopia progression. The Essilor® Stellest™ lens has been designed with an exclusive and pioneering technology called HALT (Highly Aspherical Lenslet Target). The HALT technology is made of a constellation of 1,021 invisible lenslets. This constellation creates a signal in front of the retina that acts as a shield against eye elongation and, therefore, myopia progression. Studies suggest that children are tolerable against these glasses, and the lenses can slow down myopia progression by 67% on average, compared to single vision lenses, when worn 12 hours a day. It can be considered as one of the best available myopia control spectacle lens designs, being superior to progressive addition and bifocal lenses.
SVL for children with strabismus
Also known as: Single Vision Lenses
To assess the efficacy of HAL lenses in childhood myopia control in children with strabismus and nystagmus
a. Efficacy in each eye - i. Primary outcome: change in AL in first vs second 6m ii. Secondary outcome: change in cycloplegic SE \& OCT choroidal thickness b. Alternative analysis: Difference between preferred/non-preferred eye, better-worse squint (size and control at baseline and 6m).
Time frame: 2 years
To assess the effect on strabismus (subjectively and functionally) over first vs second 6m
Primary measure: Change in squint size and control as measured by Newcastle control score (NCS)
Time frame: 2 years
Plan to share: Yes — Inclusion exclusion criteria Age Myopia progression Axial length
Supporting information: Study protocol, Informed consent form, Clinical study report
Time frame: June 2025 to June 2028
Access criteria: PI Co-PI Study members
No publications or documents are linked to this record.
Start is estimated for Jun 2025; primary completion for Jun 2028, 36 months later.
Of 25 phase 3 interventional studies under Myopia, half reached primary completion within 26 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 57. This study's planned 36 months is above that.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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Singapore National Eye Centre