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CompletedNCT06861764Updated Mar 21, 2025

The Relationship Between Preoperative Anxiety and Postoperative Delirium in Elderly Chinese Patients

An observational study in Cohort Studies, sponsored by Chinese PLA General Hospital. Completed at 1 site in China. Open to participants aged 65 Years to 100 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-21.

Sponsored by Chinese PLA General Hospital · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
8,000
Ages
65 Years to 100 Years
Sex
All
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Study summary

This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the the relationship between Preoperative Anxiety and Postoperative Delirium in Elderly Chinese Patients: a Multicenter Prospective Cohort

Read the detailed description

This is a retrospective cohort study using prospective data from a multicenter database. 8000 elderly patients undergoing elective non-cardiac or non-neurosurgical surgery were included in this study. The Generalized Anxiety Disorder Scale (GAD-7) was used to measure preoperative anxiety symptoms. The confusion assessment method (3D-CAM) was used to assess postoperative delirium in elderly patients undergoing non-cardiac surgery. If the patient is discharged, follow up by phone or email. Binary logistic regression analysis and propensity score matching (PSM) and subgroup analysis were used to analyze the data.

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Conditions studied

  • Cohort Studies

Keywords

  • preoperative anxiety
  • Aged
  • postoperative delirium
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In context

Delirium

1,057 studies on the registry are indexed under Delirium; 238 are open to participants now.

This study's enrollment of 8,000 is above the median of 200 across 418 observational studies indexed under Delirium.

Browse Delirium studies →

Lead sponsor

Chinese PLA General Hospital is the lead sponsor of 558 studies on the registry; 202 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
65 Years to 100 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Elderly patients (aged ≥ 65 years) who completed the anxiety assessment after the elective noncardiac, non-neurosurgical surgery were included in this study.

Inclusion criteria

  • elderly patients (age ≥ 65 years)
  • non-cardiac surgery, non-neurosurgical surgery

Exclusion criteria

Exclusion Criteria:

  • History of neurological or psychiatric disorders or use of neuropsychiatric drugs;
  • Impaired cognitive function or inability to cooperate with preoperative follow-up;
  • Sent to ICU after surgery;
  • Deletional delirium outcome;
  • Baseline missing >5%
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
8,000 participants (actual)
Patient registry
No

Groups and cohorts

  • Preoperative anxiety

    According to the GAD-7 scale, the population was defined as the Preoperative anxiety group

  • Non-preoperative anxiety

    According to the GAD-7 scale, the population was defined as the Non-preoperative anxiety group

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What researchers measure

Primary outcomes

  1. Postoperative delirium

    The incidence of postoperative delirium was assessed by a 3-minute diagnostic interview in the surgical ward (3D-CAM).

    Time frame: within 7 days after surgery

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Study locations

1 site
  • Chinese PLA General Hospital
    Beijing, Beijing, China
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References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 21, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06861764
Lead sponsor
Chinese PLA General Hospital
Collaborators
Beijing Tiantan Hospital, Peking University First Hospital, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Xiangya Hospital of Central South University, Beijing Anzhen Hospital, Central South University, Peking University People's Hospital, Zhejiang University, Fudan University, Sun Yat-sen University, Wuhan Union Hospital, China, China-Japan Friendship Hospital, The Affiliated Hospital Of Guizhou Medical University, First Affiliated Hospital of Xinjiang Medical University, First Affiliated Hospital of Guangxi Medical University, Taihe Hospital, Zhejiang Provincial People's Hospital, Shanghai Zhongshan Hospital
Responsible party
Weidong Mi (Director (Cheif expert of National key research and development program of China 2018YFC2001900), Chinese PLA General Hospital) — Principal investigator
First posted
Mar 6, 2025
Start date
Apr 1, 2020
Primary completion
Apr 30, 2022
Completion
Apr 30, 2022
Last update
Mar 21, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.

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