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TerminatedNCT06845150DUACLUpdated Dec 8, 2025

Combined Compared to Sequential Cognitive and Physical Training in Anterior Cruciate Ligament Reconstructed Individuals

An interventional study of Dual-task training and Single task training in Anterior Cruciate Ligament Reconstruction Rehabilitation, sponsored by Michelle C. Haas. Terminated at 2 sites in Switzerland. Open to participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2025-12-08.

Sponsored by Michelle C. Haas · Not applicable, Interventional, and Other

Why this study was terminated
Insufficient recruitment rate to reach the targeted number in June 2026
Phase
Not applicable
Study type
Interventional
Enrollment
2
Allocation
Randomized
Ages
18 Years to 40 Years
Sex
All
01

Study summary

The goal of this clinical trial is to investigate changes in cognitive and physical performance after 10 weeks of dual or single task training in anterior cruciate ligament (ACL) reconstructed individuals. The main questions it aims to answer are:

  • Does cognitive performance in ACL reconstructed individuals change after multiple training sessions incorporating single versus dual-task?
  • Does physical performance and intrinsic motivation for training change over the course of 10 weeks when performing single versus dual-task training sessions?
  • What movement patterns do ACL reconstructed individuals show during a dual-task training in an immersive environment?

Researchers will compare a combined dual-task training (combined physical and cognitive training) to a single task training (physical and cognitive training separately) to see if there are changes on cognitive performance depending on the training type.

Participants will:

  • Perform dual-task or single task training twice per week for 10 weeks
  • Visit the clinic before and after the training period for tests
  • Visit the movement laboratory once for analysis of movement patterns
02

Conditions studied

  • Anterior Cruciate Ligament Reconstruction Rehabilitation

Keywords

  • motor-cognitive training
  • dual-task training
  • anterior cruciate ligament injury
  • return to competition
03

In context

Anterior Cruciate Ligament Injuries

512 studies on the registry are indexed under Anterior Cruciate Ligament Injuries; 164 are open to participants now.

This study's enrollment of 2 is below the median of 56 across 373 interventional studies indexed under Anterior Cruciate Ligament Injuries.

Browse Anterior Cruciate Ligament Injuries studies →

Lead sponsor

This is the only study on the registry with Michelle C. Haas as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 40 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • 18-40 years old
  • At least 6 months after ACL injury
  • Surgically reconstructed ACL
  • At least 2 hours of sports participation before the injury
  • Written consent of the attending surgeon to perform intensified training methods including one-legged jumps at 6 months after surgery after the first visit
  • Ability to give informed consent as documented by signature
  • Ability to understand instructions in German or English
  • BMI \< 28 kg/m\^2
  • Availability to take part in at least 70% of all training sessions

Exclusion criteria

Exclusion Criteria:

  • Surgery on the contralateral leg during the last 12 months
  • Acute or chronic musculoskeletal, neurological, or cardiopulmonary disorders
  • Unadjusted vision problems
  • Concussion during the last 6 months
  • Pregnancy
  • Breastfeeding
  • Amputation
  • Inflammatory pain or swelling during exercising
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
2 participants (actual)

Study arms

  • Experimental
    Dual-task training

    Other: Dual-task training

  • Active comparator
    Single task training

    Other: Single task training

Interventions

  • OtherDual-task training

    Combined simultaneous physical and cognitive training in an immersive environment

  • OtherSingle task training

    Sequential cognitive and then physical training

06

What researchers measure

Primary outcomes

  1. Interference

    Measured by the difference in reaction time of congruent and incongruent stimuli of the Flanker task.

    Time frame: Baseline, after 5 weeks of training, after 10 weeks of training

  2. Response inhibition

    Measured by the accuracy of Go/No-Go-stimuli

    Time frame: Baseline, after 5 weeks of training, after 10 weeks of training

Secondary outcomes

  1. Jumping performance - contact time

    Contact time during jumping on force plates.

    Time frame: Baseline and after 10 weeks of training

  2. Jumping performance - peak force

    Peak force during jumping on force plates.

    Time frame: Baseline and after 10 weeks of training

  3. Strength

    Peak force of hamstring, quadriceps, hip abduction, and hip adduction

    Time frame: Baseline and after 10 weeks of training

  4. Intrinsic motivation

    German version of the short scale for intrinsic motivation (Kurzskala Intrinsische Motivation). For each of the 12 items there is a 5-point Likert-Scale resulting in values of 0-4. Therefore, the total score ranges from 0 to 48. The higher the score, the higher the intrinsic motivation.

    Time frame: At the end of each training session (2x/week for 10 weeks)

  5. Kinematics and kinetics of the lower extremities

    Hip, knee, and ankle angles and moments and ground reaction forces

    Time frame: During dual-task training in an immersive environment

  6. Kinematics and kinetics of the lower extremities

    Ground reaction forces, angles and moments of hip, knee, and ankle during functional tasks

    Time frame: Baseline and after 10 weeks of training

Other outcomes

  1. Kujala

    The German version of the 13-item Kujala questionnaire will be used for assessment of anterior knee pain. Questions involve ability to do several activities and symptoms of patients. All scores of the 13 items are summed up to give a total score ranging from 0 to 100. High scores indicate a good outcome.

    Time frame: Baseline and after 10 weeks of training

  2. ACL-Return to Sport after Injury Scale

    The German version of the ACL-RSI will be used. The ACL-Return to Sport after Injury Scales includes 12 items which are each answered on a Likert-scale from 0 to 100. For the total score, individual scores of each item are added and subsequently divided by the numer of questions. Hence total score ranges from 0 to 120. High scores indicate a positive psychological evaluation.

    Time frame: Baseline and after 10 weeks of training

  3. Tegner Activity Scale

    The German version of the Tegner Activity Scale including 11 different stages will be used. Each stage includes activities in sports and work of patients after ACL injury. Stages range from 0 to 10.

    Time frame: Baseline and after 10 weeks of training

  4. Socio-demographic data

    Sex, age, time since ACL reconstruction, injury history

    Time frame: Baseline

  5. Subjective Cognitive Load

    Measured by the NASA-TLX questionnaire

    Time frame: At the end of each training session (2x/week for 10 weeks)

07

Study locations

2 sites
  • KSW Kantonsspital Winterthur
    Winterthur, 8000, Switzerland
  • ZHAW Zurich University of Applied Sciences
    Winterthur, 8000, Switzerland
08

References and documents

Individual participant data

Plan to share: Yes — Individual participant data will be shared if ethically and legally possible.

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 8, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06845150
Lead sponsor
Michelle C. Haas
Collaborators
Kantonsspital Winterthur KSW, ZHAW DIZH Fellowship Program
Responsible party
Michelle C. Haas (Research Associate, Zurich University of Applied Sciences) — Sponsor-investigator
First posted
Feb 25, 2025
Start date
Jun 5, 2025
Primary completion
Jun 12, 2025
Completion
Oct 8, 2025
Last update
Dec 8, 2025

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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