A Phase 2 interventional study of Alvogyl and Eugenol in Alveolar Osteitis, sponsored by HITEC-Institute of Medical Sciences. Not yet recruiting at 1 site in Pakistan. Open to participants aged 16 Years to 70 Years. Per ClinicalTrials.gov, last updated 2025-02-12.
Sponsored by HITEC-Institute of Medical Sciences · Phase 2, Interventional, and Treatment
Dry socket the unscientific term also known as alveolar or fibrinolytic osteitis is the most common postoperative complication following tooth extraction.
Treatment of Alveolar osteitis can be either pharmacological on non-pharmacological. Management can be by irrigation, surgical intervention and placement of medicated dressing such as topical anti-bacterial, topical anesthetics and obtundants or combination of these three.this study aims to find the best and effective treatment for dry socket comparing Alveogyl, Eugenol and Black seed oil at this institution.
Dry socket the unscientific term also known as alveolar or fibrinolytic osteitis is the most common postoperative complication following tooth extraction. Dry socket lesion occur in approximately 1% to 5% of all extraction and up to 38% of mandibular third molar extractions. The etiology of dry socket is not yet fully understood, however the disintegration of the blood clot at the site of the tooth extraction fails to develop i.e. fibrinolysis is widely accepted as the primary mechanism or it dislodges before wound has healed. Various factors have been associated with an increase of dry socket, although some of them remain controversial and many include difficult or traumatic extractions, oral hygiene, smoking, Gender (female), extraction site, previous dry socket history, while incidence can be reduced with the chlorhexidine rinse and gel of alveolar osteitis.
Treatment of Alveolar osteitis can be either pharmacological on non-pharmacological. Management can be by irrigation, surgical intervention and placement of medicated dressing such as topical anti-bacterial, topical anesthetics and obtundants or combination of these three. Out of these Alveogyl is the still the material of choice in terms of pain relief, wound healing and low incidence of dry socket as compared to honey, zinc oxide eugenol and cutanplast , however in some recent studies a mixture of Nigella sativa powder and oil showed that it is more efficacious dressing material for the management of dry socket compared to alvogyl, it provided immediate and complete pain relief and fewer number of repeated visits needed while in some neocane was the most suitable dressing material for the management of dry socket by virtue of shorter time required for the complete pain relief, fewer visits required and faster clinical healing. Based on the previous data, we decided to conduct a study to evaluate the effectiveness of nigella sativa (black seed oil) for the treatment of dry socket compared to alveogyl and eugenol both. To the best of our knowledge, this is the first comparative study of nigella sativa oil for the treatment of dry socket at Oral and maxillofacial surgery department, HITEC dental college, Taxila and is aimed to find the best and effective treatment for dry socket comparing Alveogyl, Eugenol and Black seed oil at this institution.
46 studies on the registry are indexed under Dry Socket; 10 are open to participants now.
This study's planned enrollment of 40 is below the median of 60 across 41 interventional studies indexed under Dry Socket.
Browse Dry Socket studies →HITEC-Institute of Medical Sciences is the lead sponsor of 14 studies on the registry; 2 are open to participants now.
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Exclusion Criteria:
this group will be assigned Alvogyl as treatment drug
Drug: Alvogyl
this group will be assigned Eugenol as treatment drug
Drug: Eugenol
this group will be assigned Nigella Sativa as treatment drug
Drug: Nigella Sativa Oil
this is standard treatment drug
this not standard drug for the treatment of Alveolar Osteitis but an antiseptic agent
it not standard medicine for Alveolar Osteitis. it is a herbal medicine
Visual Analogue Scale
pain will assessed using Visual Analogue scale on day 2, 6, 10 and 14th after the start of treatment. Visual Analogue Score measurement will be scale based from 1 to 10 score. Where 1-3 is mild, 3-7 is moderate and 7-10 will be scored as severe pain.
Time frame: 14 days
Periodontal Probe
alveolar osteitis affected extraction socket will be observed for the resolution of inflammation and healing will be assessed on day 2, 6, 10 and 14 by clinical examination with periodontal Probe. Periodontal depth will be measured in mm, by using the periodontal probe where the depth of 1 to 3 mm is considered well healed socket, 4-6 mm indicates moderately inflamed, 7 mm and above is considered severely inflammed .
Time frame: 14 days
Plan to share: No — its not required for trial registry. if at any time during trial registration it is asked , i will provide the data
No publications or documents are linked to this record.
Start is estimated for Feb 2025; primary completion for Jul 2025, 5 months later.
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This study is not yet recruiting, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Butyl aminobenzoate, eugenol, iodoform, spearmint oil drug combinations · Nigella sativa oil
HITEC-Institute of Medical Sciences