A Phase 1 interventional study of Clomiphene Citrate and letrozole in Polycystic Ovarian Syndrome, sponsored by HITEC-Institute of Medical Sciences. Completed at 1 site in Pakistan. Open to female participants aged 20 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-07.
Sponsored by HITEC-Institute of Medical Sciences · Phase 1, Interventional, and Treatment
Clomiphene citrate resistant i.e failure to ovulate after 6 cycles of ovulation induction effects 15-40% of patients with PCOS.Two treatment groups will be formed one recieving letrozole alone and another recieving CC and letrozole combined.Mature follicles and endometrial thickness will be checked by transvaginal ultrasound and results will be recorded.
Subfertility is characterized by the inability to achieve conception despite engaging in regular unprotected sexual intercourse for 1-2 years.PCOS exhibits chacteristic traits such as obesity,heightened insulin resistance accompanied by compensatory hyperinsulinemia,oligo/anovulation and subfertility.Clompiphene citrate induces ovarian stimulation.Letrozole ,an aromatase inhibitor emerges as a novel medication with comparable efficacy to CC as a first line treatment for inducing ovulation in cases of anovulation.
944 studies on the registry are indexed under Polycystic Ovary Syndrome; 174 are open to participants now.
This study's enrollment of 42 is below the median of 70 across 685 interventional studies indexed under Polycystic Ovary Syndrome.
Browse Polycystic Ovary Syndrome studies →HITEC-Institute of Medical Sciences is the lead sponsor of 14 studies on the registry; 2 are open to participants now.
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Exclusion Criteria:
clomiphene citrate and letrozole combination
Drug: Clomiphene Citrate and letrozole
letrozole alone
Drug: Clomiphene Citrate and letrozole
clomiphene citrate 100mg once daily along with letrozole 5mg to one group and letrozole 5mg to second group
Also known as: drugs
To compare the rate of ovulation
To compare the rate of ovulation between letrozole alone and letrozole and CC
Time frame: 6 months
Plan to share: No
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HITEC-Institute of Medical Sciences