A Phase 4 interventional study of Liposomal bupivacaine (LB) and Dexamethasone in Hand Surgery, Wrist Surgery and Elbow Surgery, sponsored by St. Luke's Hospital, Pennsylvania. Active, not recruiting at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-02-06.
Sponsored by St. Luke's Hospital, Pennsylvania · Phase 4, Interventional, and Treatment
Patients undergoing hand, wrist, and elbow surgery may experience pain after surgery. The orthopedic surgeon may provide prescription pain medications after surgery to assist with pain control. However, with concern of the opioid epidemic, many patients would rather minimize the use of narcotic pain prescriptions after having surgery. As an alternative, ultrasound guided regional nerve blocks can assist with postoperative pain control.
patients consented to this study will be randomized into three groups: 1) will receive an ultrasound guided nerve block with local anesthesia only, 2) will receive an ultrasound guided nerve block with local anesthesia and a steroid dexamethasone, 3) will receive an ultrasound guided nerve block with liposomal bupivacaine.
our study team will make phone calls after surgery to the patient to determine how long the block lasted for, and how many opioid pain pills were taken up to 3 days after surgery.
Our study team predicts that the ultrasound guided nerve block with liposomal bupivacaine can last approximately 48 hours, while the block with local anesthesia and dexamethasone will last approximately 30 hours, and the block with local anesthesia only may last up to 24 hours
78 studies on the registry are indexed under Dupuytren Contracture; 18 are open to participants now.
This study's planned enrollment of 120 is above the median of 72 across 57 interventional studies indexed under Dupuytren Contracture.
Browse Dupuytren Contracture studies →St. Luke's Hospital, Pennsylvania is the lead sponsor of 18 studies on the registry; 2 are open to participants now.
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Exclusion Criteria:
ultrasound guided supraclavicular nerve blocks are typically performed with the use of local anesthesia only
dexamethasone is a potent steroid that when provided in ultrasound guided nerve blocks can extend the duration of the nerve block.
Drug: Dexamethasone
our study team would like to determine how use of liposomal bupivacaine in supraclavicular nerve blocks can lengthen the duration of the nerve block, and how it may affect the number of opioid pills used after surgery up until postoperative day three.
Drug: Liposomal bupivacaine (LB)
our study team wishes to determine effect of liposomal bupivacaine in regional nerve blocks for surgery of the upper extremity (finger, hand, wrist, elbow)
Also known as: liposomal bupivacaine, exparel
dexamethasone injected in perineural area can extend the regional nerve block
Also known as: decadron perineural injection
Subjective length of duration of block
our study team contacts the patients 4 days after surgery to ask how long their regional nerve block lasted
Time frame: feedback obtained up until day 3 after surgery
Number of opioid pills taken until postoperative day 3
our study team contacts the patients to ask how many opioid pain pills were taken from arrival to home up until postoperative day 3
Time frame: feedback until day 3 after surgery
Plan to share: Yes — we will provide results on our measured outcomes: subjective length of duration of block, number of opioid pills taken by postsurgical day 3. we will provide de-identified information on demographics as well between the control arm and treatment arms
Supporting information: Study protocol, Statistical analysis plan, Clinical study report
Time frame: we will provide deidentified data on patients participating within the start to end dates of patient recruitment. This data will be available to view in anticipated publication to a journal
Access criteria: This information can be available to view after publication to a journal.
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Jan 2025. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Liposomal Bupivacaine · Dexamethasone
St. Luke's Hospital, Pennsylvania