ClinicalTrials.gg
RecruitingNCT06801743IRMESVUpdated Feb 13, 2025

WHEN DO WE HAVE to PERFORM CARDIAC MAGNETIC RESONANCE in PATIENTS REFERRED for PREMATURE VENTRICULAR COMPLEXES by THEIR CARDIOLOGISTS

An observational study in Premature Ventricular Complexes, Ventricular Arythmias and Cardiac Magnetic Resonance Imaging, sponsored by Centre Hospitalier Universitaire, Amiens. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-02-13.

Sponsored by Centre Hospitalier Universitaire, Amiens · Observational

From the registry’s dates

  • Primary completion was expected by Nov 2025, 1 year ago, but the record still lists the study as recruiting.
  • Started Nov 2024; still recruiting 1 year 11 months later.
Study type
Observational
Model
Case-only
Time perspective
Other
Enrollment
200
Ages
18 Years and older
Sex
All
01

Study summary

Premature ventricular complexes (PVC) are a common entity affecting approximatively 20% of the general population. It can be discovered incidentally on electrocardiogram (ECG) or associated with symptoms with a wide spectrum from palpitations, chest pain, to syncope.

The initial and non invasive assessment includes holter ECG monitoring, a transthoracic echocardiography (TTE) and an exercise stress test to rule out structural heart disease (SHD), and referred to as benign or "idiopathic" ventricular arrhythmias (IVA).

However, these exams may fail to identify subtle myocardial abnormalities such as arrhythmogenic right ventricle dysplasia (ARVD), apical hypertrophic cardiomyopathy, healed myocarditis, ischemic or non-ischemic cardiomyopathies.

Cardiac magnetic resonance (CMR) imaging is the gold standard modality to assess regional and global ventricular function. It is also a unique modality to non-invasively detect myocardial edema, myocardial fatty replacement, focal and diffuse fibrosis and could potentially identify SHD in patients with PVC.

However, the role of CMR is uncertain, recommended in case of atypical presentation or when the initial assessment can't exclude a cardiomyopathy (recommendations class IIa).

This study sought to determine whether and when CMR can be performed to provide diagnosis or prognostic information complementary to initial assessment in patients referred for PVC by their cardiologists.

02

Conditions studied

  • Premature Ventricular Complexes
  • Ventricular Arythmias
  • Cardiac Magnetic Resonance Imaging
  • Focal or Diffuse Fibrosis
  • Structural Heart Disease
  • Idiopathic

Keywords

  • premature ventricular complexes
  • ventricular arythmias
  • cardiac magnetic resonance
  • focal or diffuse fibrosis
  • structural heart disease
  • idiopathic
03

In context

Ventricular Premature Complexes

102 studies on the registry are indexed under Ventricular Premature Complexes; 32 are open to participants now.

This study's planned enrollment of 200 is above the median of 125 across 39 observational studies indexed under Ventricular Premature Complexes.

Browse Ventricular Premature Complexes studies →

Lead sponsor

Centre Hospitalier Universitaire, Amiens is the lead sponsor of 586 studies on the registry; 185 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

patients with PVC who have performed ECG, Holter ECG and a CMR

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • patients with PVC who have performed , Holter ECG and a CMR

Exclusion criteria

Exclusion Criteria:

  • patient showing opposition tu use his personal data for the reseach,
  • patient unable to express his opposition,
  • patient deprived of liberty,
  • patient with language issues (speaking or writing French)
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

ECG (electrocardiogram)

A recording of the heart’s electrical activity, taken with stickers on the chest, arms and legs. It takes a few minutes and does not hurt.

05

Study design

Observational model
Case-only
Time perspective
Other
Enrollment
200 participants (estimated)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Number of myocardial abnormalities identified by CMR

    Composite endpoint of myocardial abnormalities identified by CMR including dilated cardiomyopathy, hypertrophic cardiomyopathy, ischemic cardiomyopathy, ventricular non-compaction, ARVD, myocarditis, pericarditis, sarcoidosis, amyloidosis, Fabry disease

    Time frame: 1 day

Secondary outcomes

  1. number of criteria to predict myocardial abnormalities on CMR

    Time frame: day 1

07

Study locations

1 of 1 sites recruiting
  • Centre Hospital-Universitaire d'Amiens
    Salouel, 80480, France
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 13, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06801743
Responsible party
Sponsor
First posted
Jan 30, 2025
Start date
Nov 27, 2024
Primary completion
Nov 2025 (estimated)
Completion
May 2026 (estimated)
Last update
Feb 13, 2025

Study contacts

Emmanuelle VERMES, MD
Contact
vermes.emmanuelle@chu-amiens.fr
33 + 322087302

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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