An observational study in Premature Ventricular Complexes, Diet Quality and Biochemical Markers, sponsored by Izmir Democracy University. Not yet recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-13.
Sponsored by Izmir Democracy University · Observational
The aim of this study is to evaluate differences in energy, macro- and micronutrient intakes, dietary characteristics, quality of life, and biochemical parameters between individuals with and without premature ventricular complexes. The study will include a total of 100 adults who present to the Cardiology Outpatient Clinic of Buca Seyfi Demirsoy Training and Research Hospital, comprising 50 individuals with premature ventricular complexes and 50 healthy individuals. Participants will be instructed to discontinue caffeine-containing beverages, stimulants, and medications that may affect cardiac rhythm for 72 hours prior to Holter monitoring. The diagnosis of premature ventricular complexes will be established by a specialist cardiologist. Dietary intake will be assessed using three non-consecutive 24-hour dietary recalls, including two weekdays and one weekend day. Dietary intake data will be collected by the researcher through face-to-face interviews and recorded on the study questionnaire. The Dietary Inflammatory Index (DII) and Healthy Eating Index will be calculated based on the participants' three-day dietary intake data. No additional blood samples or biochemical tests will be requested specifically for the purposes of this study. Instead, the participants' most recent biochemical parameters obtained as part of routine clinical care will be retrieved from their medical records. These parameters will include fasting blood glucose (mg/dL), glycated hemoglobin (HbA1c, %), total cholesterol (mg/dL), high-density lipoprotein cholesterol (HDL-C, mg/dL), low-density lipoprotein cholesterol (LDL-C, mg/dL), triglycerides (mg/dL), vitamin D, and other routinely assessed biochemical parameters. The results will be interpreted according to the reference ranges used by Buca Seyfi Demirsoy Training and Research Hospital. Participants' quality of life will be assessed using the 36-Item Short Form Health Survey (SF-36).
Although premature ventricular contractions are among the most common types of arrhythmia in patients both with and without structural heart disease, they may lead to long-term left ventricular dysfunction in patients with structurally normal hearts. An increased frequency of premature ventricular complexes (PVCs) may be associated with mental and physical stress, lifestyle-related factors, as well as cardiovascular risk factors such as hypertension, dyslipidemia, diabetes mellitus, and coronary artery disease. Frequent PVCs may lead to tachycardiomyopathy and, consequently, increased morbidity and mortality. The aim of this study is to evaluate differences in energy, macro- and micronutrient intakes, dietary characteristics, quality of life, and biochemical parameters between individuals with and without premature ventricular complexes. The study will include a total of 100 adults who present to the Cardiology Outpatient Clinic of Buca Seyfi Demirsoy Training and Research Hospital, comprising 50 individuals with premature ventricular complexes and 50 healthy individuals. Participants will be instructed to discontinue caffeine-containing beverages, stimulants, and medications that may affect cardiac rhythm for 72 hours prior to Holter monitoring. The diagnosis of premature ventricular complexes will be established by a specialist cardiologist. Dietary intake will be assessed using three non-consecutive 24-hour dietary recalls, including two weekdays and one weekend day. Dietary intake data will be collected by the researcher through face-to-face interviews and recorded on the study questionnaire. The Dietary Inflammatory Index (DII) and Healthy Eating Index will be calculated based on the participants' three-day dietary intake data. No additional blood samples or biochemical tests will be requested specifically for the purposes of this study. Instead, the participants' most recent biochemical parameters obtained as part of routine clinical care will be retrieved from their medical records. These parameters will include fasting blood glucose (mg/dL), glycated hemoglobin (HbA1c, %), total cholesterol (mg/dL), high-density lipoprotein cholesterol (HDL-C, mg/dL), low-density lipoprotein cholesterol (LDL-C, mg/dL), triglycerides (mg/dL), vitamin D, and other routinely assessed biochemical parameters. The results will be interpreted according to the reference ranges used by Buca Seyfi Demirsoy Training and Research Hospital. Participants' quality of life will be assessed using the 36-Item Short Form Health Survey (SF-36).
96 studies on the registry are indexed under Ventricular Premature Complexes; 29 are open to participants now.
This study's planned enrollment of 100 is below the median of 113 across 36 observational studies indexed under Ventricular Premature Complexes.
Browse Ventricular Premature Complexes studies →Izmir Democracy University is the lead sponsor of 76 studies on the registry; 34 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study will include 50 individuals with premature ventricular complexes (PVCs) and 50 healthy adults who present to the Cardiology Outpatient Clinic of Buca Seyfi Demirsoy Training and Research Hospital. Participants will be asked to discontinue caffeine-containing beverages, stimulants, and medications that may affect cardiac rhythm for 72 hours prior to Holter monitoring. The diagnosis of premature ventricular complexes will be established by a specialist cardiologist.
Inclusion Criteria:
Inclusion criteria for individuals with premature ventricular complexes (PVCs):
Inclusion criteria for healthy individuals:
Exclusion Criteria:
Exclusion criteria for individuals with premature ventricular complexes (PVC):
Exclusion criteria for healthy individuals:
The study will include 50 individuals with premature ventricular complexes who present to the Cardiology Outpatient Clinic of Buca Seyfi Demirsoy Training and Research Hospital.
Diet Inflammatory Index
The Dietary Inflammatory Index will be calculated for patients with premature ventricular complexes
Time frame: From enrollment to the end of treatment at 2 years
Diet Quality
Diet quality will be assessed using the Diet Quality Index-International (DQI-I) scoring system
Time frame: From enrollment to the end of treatment at 2 years
Food Variety
Participants' dietary variety will be determined using 3-day dietary records
Time frame: From enrollment to the end of treatment at 2 years
Glucose
Serum glucose will be obtained from the participants' routine blood parameters.
Time frame: From enrollment to the end of treatment at 2 years
Hemoglobin A1c
The data will be obtained from the participants' routine blood test results.
Time frame: From enrollment to the end of treatment at 2 years
Total Cholesterol
The data will be obtained from the participants' routine blood test results.
Time frame: From enrollment to the end of treatment at 2 years
High Density Lipoprotein
The data will be obtained from the participants' routine blood test results.
Time frame: From enrollment to the end of treatment at 2 years
Low Density Lipoprotein
The data will be obtained from the participants' routine blood test results.
Time frame: From enrollment to the end of treatment at 2 years
Trygliseride
The data will be obtained from the participants' routine blood test results.
Time frame: From enrollment to the end of treatment at 2 years
Vitamin D
The data will be obtained from the participants' routine blood test results.
Time frame: From enrollment to the end of treatment at 2 years
Life Quality
The Short Form-36 Health Survey will be used to assess the participants' quality of life.
Time frame: From enrollment to the end of treatment at 2 years
Plan to share: No — Individual participant data (IPD) will not be shared to protect participant confidentiality and ensure compliance with data privacy requirements.
Start is estimated for Nov 2026; primary completion for Nov 2027, 12 months later.
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From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Izmir Democracy University