A Phase 4 interventional study of Carboxytherapy and Placebo in Liposuction, Bruising and Inflammation, sponsored by Total Definer Research Group. Completed at 3 sites in 3 countries. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-21.
Sponsored by Total Definer Research Group · Phase 4, Interventional, and Prevention
The goal of this clinical trial is to evaluate if CO2 Lift reduces bruising and pain after Liposuction. The study also aims to explore changes in patient satisfaction. The main questions this study seeks to answer are:
In this study, researchers will compare CO2 lift to a placebo (Vaseline) to see if the intervention has a positive effect.
The study procedures include:
Study Design: Randomized, controlled, single-blind trial
Study Locations:
Data Collection:
Ethical Considerations:
43 studies on the registry are indexed under Contusions; 8 are open to participants now.
This study's enrollment of 72 is below the median of 90 across 31 interventional studies indexed under Contusions.
Browse Contusions studies →Total Definer Research Group is the lead sponsor of 6 studies on the registry; 1 is open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
* Application of CO2 lift to one arm, and/or one glute, and/or one half of the lower abdomen. * Apply immediately after surgery and 12 hours later. Then one time per day for 3-5 days for patients with low risk for flap/skin ischemia/suffering.
Drug: Carboxytherapy
\* Application of Vaseline to the contralateral area in which CO2 lift was applied, using the same timing protocol as per CO2 lift
Other: Placebo
Application of the intervention (CO2 Lift) in the area according to the protocol schedule
Application of the placebo (Vaseline) in the area according to the protocol schedule
Ecchymosis of the area - 7 days post procedure
Reduction of ecchymosis in each area, measured using Photomicrographic analysis with ImageJ Software. The unit of measurement will me in cm\^2 of the affected area (bruised) normalized to the total area of the area (in cm\^2).
Time frame: 7 days
Ecchymosis of the area - 24 hours post procedure
Reduction of ecchymosis in each area, measured using Photomicrographic analysis with ImageJ Software. The unit of measurement will me in cm\^2 of the affected area (bruised) normalized to the total area of the area (in cm\^2).
Time frame: 24 hours
Ecchymosis of the area - 3 days post procedure
Reduction of ecchymosis in each area, measured using Photomicrographic analysis with ImageJ Software. The unit of measurement will me in cm\^2 of the affected area (bruised) normalized to the total area of the area (in cm\^2).
Time frame: 3 days
Pain Score
Patient-reported pain measured using Pain Visual Analogue Scale (VAS), measured at 24 hours, 3 days, and 7 days post-procedure. In the VAS pain scores, 0 represents no pain, while 10 represents the worst possible pain experienced.
Time frame: 7 days
Patient Satisfaction Scores
Patient reported satisfaction scores measured using Global Aesthetic Improvement Scale (GAIS). The GAIS is a standardized scale used primarily in cosmetic and dermatological treatments to assess the overall aesthetic improvement of a patient after a procedure. It consist of three questions: \* how do you feel about your appearance after surgery? Possible answers: Very much improved, much improved, slightly improved, no change. \* Are you satisfied with the surgery? Very satisfied, satisfied, not satisfied. \* Would you recommend the surgical procedure? Possible answers: Yes, perhaps, no.
Time frame: 6 months
Plan to share: Yes — Depending upon reasonable request
Supporting information: Study protocol, Statistical analysis plan, Clinical study report
Time frame: Immediately after publication.
Access criteria: Request to the main author
Ran from Sep 2023 to primary completion in Jun 2025, 21 months.
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This study is completed, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Total Definer Research Group