An interventional study of Carbohydrate-first meal and Carbohydrate-last meal in Glucose Metabolism Disorders, Hunger and Fat Burn, sponsored by Old Dominion University. Completed at 1 site in United States. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-16.
Sponsored by Old Dominion University · Not applicable, Interventional, and Basic science
Consuming a carbohydrate-rich food as the final food in a meal, as compared to the first food in a meal, has been shown to reduce blood glucose levels after eating in both diabetes patients and in healthy controls. However, gaps remain in the literature in this area of research, and currently little is known about how substrate (fuel) use is impacted by altering food order. In addition, most studies to date have used a mix of meat and plant foods, while little research has focused exclusively on vegetarian foods. This randomized experiment will examine how altering the order of foods eaten in a vegetarian meal impacts blood glucose and fuel utilization at rest.
361 studies on the registry are indexed under Glucose Metabolism Disorders; 38 are open to participants now.
This study's enrollment of 50 is below the median of 60 across 308 interventional studies indexed under Glucose Metabolism Disorders.
Browse Glucose Metabolism Disorders studies →Old Dominion University is the lead sponsor of 27 studies on the registry; 4 are open to participants now.
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Exclusion Criteria:
Other: Carbohydrate-first meal
Other: Carbohydrate-last meal
Rice eaten first (150 grams), followed by edamame (150 grams) and butter (10 grams)
Edamame (150 grams) and butter (10 grams) eaten first, followed by rice (150 grams)
Respiratory exchange ratio
Ratio of carbon dioxide production and oxygen consumption for determination of fuel use
Time frame: 90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal)
Fat use
Fat utilization will be estimated from respiratory gas exchange
Time frame: 90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal)
Carbohydrate use
Carbohydrate utilization will be estimated from respiratory gas exchange
Time frame: 90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal)
Blood glucose
Blood glucose will be measured with fingerstick samples and a portable glucometer
Time frame: 90 minutes (baseline/premeal and 30, 60, and 90 minutes postmeal)
Hunger-satiety perceptions
Hunger, appetite, satiety, and fullness on a 0-10 Likert scale
Time frame: 90 minutes (baseline/premeal and 30, 60, and 90 minutes postmeal)
Plan to share: Yes — De-identified IPD will be shared as supplementary material associated with the published peer-reviewed publication or through a publicly available repository (depending on the journal's preference).
Time frame: Data will become available once the associated article is officially published. The data will be made available indefinitely.
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Glucose Metabolism Disorders →
Old Dominion University