An interventional study of removal of exercise in Glucose Intolerance, Exercise and Vascular Function, sponsored by Old Dominion University. Recruiting at 1 site in United States. Per ClinicalTrials.gov, last updated 2024-04-10.
Sponsored by Old Dominion University · Not applicable, Interventional, and Basic science
The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.
793 studies on the registry are indexed under Glucose Intolerance; 115 are open to participants now.
This study's planned enrollment of 40 is below the median of 56 across 661 interventional studies indexed under Glucose Intolerance.
Browse Glucose Intolerance studies →Old Dominion University is the lead sponsor of 27 studies on the registry; 4 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The human immunodeficiency virus, which weakens the immune system.
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HIV
The human immunodeficiency virus, which weakens the immune system.
Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Metabolic: Participants will have their blood glucose levels measured via continuous glucose monitoring for 3 days while participating in their normal exercise routines (EX). Participants will also have their blood glucose levels measured for 3 days while not exercising (NOEX), following immediately by 3 days of a return to normal activity(REX). Participants will be randomized to participate in the EX or NOEX/REX phases first. The EX and NOEX/REX phases will be separated by at least 1 week
Other: removal of exercise
Vascular: Participants will have their blood vessel health measured while performing their normal exercise routines (EX) and while undergoing 1, 3, 5 days of no exercise (NOEX) followed immediately by 1 and 3 days of return to exercise (REX).
Other: removal of exercise
Subjects will stop doing their normal exercise routines for 3 or 5 days and then subjects will resume doing their normal exercise routines for 3 days.
Also known as: return to exercise
Continuous glucose monitoring
Time frame: 3 days before removal of exercise
Continuous glucose monitoring
Time frame: After removal of exercise for 5 days
Continuous glucose monitoring
Time frame: After return to exercise for 3 days
Flow mediated dilation
This measure assess blood vessel health non-invasively
Time frame: 3 days before removal of exercise
Flow mediated dilation (vascular health)
This measure assess blood vessel health non-invasively
Time frame: After removal of exercise for 5 days
Flow mediated dilation (vascular health)
This measure assess blood vessel health non-invasively
Time frame: After return to exercise for 3 days
Plan to share: Undecided
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Old Dominion University