An observational study in Osteoporosis, Sarcopenia and Ultrasonography, sponsored by Istanbul University - Cerrahpasa. Completed at 2 sites in Turkey (Türkiye). Open to female participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2025-01-08.
Sponsored by Istanbul University - Cerrahpasa · Observational
To determine the impact of thoracic hyperkyphosis, sarcopenia and quadriceps muscle thickness evaluated by ultrasonography (USG) on balance, fall risk and functional parameters in women with postmenopausal osteoporosis, to assess their interrelationships and to compare the clinical characteristics of sarcopenia and thoracic hyperkyphosis.
An observational study was conducted on patients with PMO and/or osteoporotic vertebral fractures according to WHO criteria. One hundred seventeen patients who were 50 years of age or older, with a diagnosis of PMO and/or osteoporotic vertebral fractures according to WHO criteria, who were able to ambulate without any assistive devices were included in the study. Patients with a history of neurological disease which may affect balance and proprioception, visual and vestibular disease, previous major lower extremity surgery or previous vertebra surgery were excluded. The investigators also excluded the patients with advanced heart, liver, or renal failure, stage 4 knee osteoarthritis, psychiatric disorders, and use of any medication affecting the central nervous system.
Age, height, weight, body mass index (BMI), comorbidities, medications, previous surgeries, steroid use, previous fractures and the energy level of these fractures (low or high), fracture location, family history of fractures, alcohol use, smoking, menopausal age and the number of falls in a year were questioned. The FRAX algorithm was used to determine the risk of fracture.
The Cobb angle of thoracic kyphosis was calculated radiographically and QFM thickness was measured from anterior thigh via ultrasonography (USG). The presence of sarcopenia was determined. Balance, fall risk and physical function were evaluated with tandem stance and gait test, Berg balance scale (BBS), Timed up and go test (TUG), hand grip strength, chair stand test (CST).
1,675 studies on the registry are indexed under Osteoporosis; 211 are open to participants now.
This study's enrollment of 103 is below the median of 180 across 461 observational studies indexed under Osteoporosis.
Browse Osteoporosis studies →Istanbul University - Cerrahpasa is the lead sponsor of 693 studies on the registry; 213 are open to participants now.
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Patients aged 50 years and over with postmenopausal osteoporosis and/or osteoporotic vertebral fractures according to WHO criteria who applied to the outpatient clinic of the Department of Physical Medicine and Rehabilitation, Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine
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Exclusion Criteria:
tandem stance and gait test
static and dynamic balance was measured.
Time frame: Data were collected over a single measurement period of 6 months.
berg balance scale
Berg balance scale was originally developed for the assessment of postural control and is widely used in many areas of rehabilitation. There are 14 items in the scale, like commonly performing in daily activities sitting and standing balance, transfers, turning, and retrieving objects from the floor. The highest total score is 56 points. If the patient scores between 0-20 points, they are considered wheelchair dependent, between 21-40 points they can walk with assistance and between 41-56 points they are considered independent in mobilization activities.
Time frame: Data were collected over a single measurement period of 6 months.
Timed up and go test
There is a significant relationship between TUG times and functional mobility level
Time frame: Data were collected over a single measurement period of 6 months.
chair stand test
The five times CST evaluates the strength, power, and endurance of the lower extremity muscle group, particularly the quadriceps femoris muscle
Time frame: Data were collected over a single measurement period of 6 months.
quadriceps femoris muscle thickness
evaluated by ultrasound
Time frame: Data were collected over a single measurement period of 6 months.
thoracic kyphosis
The lateral thoracic vertebra radiographs were taken while standing position, the Cobb angle was automatically obtained by computer-aided method by marking the parallel lines drawn from the upper edge of the upper thoracic vertebra (T4), and the lower edge of the lower thoracic vertebra (T12)
Time frame: Data were collected over a single measurement period of 6 months.
Plan to share: Yes — all IPD that underlie results in a publication
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report
Time frame: 12 months after publication of primary results
Access criteria: Academic and Clinical Researchers, Regulatory Authorities and Non-commercial Researchers and Public Health Organizations can access the data Demographic and Clinical Data, Outcome Measures,Study protocols, statistical analysis plans, and publications can be accessed Submit a Request, Approval Process, Secure Access will be accessed
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This study is completed, as verified in Jan 2025. You cannot join it, but the record below documents what was studied.
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