An observational study in Spinal Anesthesia-Induced Hypotension, sponsored by Konya City Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2025-11-17.
Sponsored by Konya City Hospital · Observational
This prospective observational study aims to evaluate predictive factors for spinal anesthesia-induced hypotension (SASH) in hypertensive patients undergoing elective surgery. Parameters such as internal jugular vein collapsibility index, carotid intima-media thickness, and flow-mediated dilation will be assessed using ultrasonography to determine their association with SASH. Demographic, anthropometric, and hemodynamic data will also be analyzed. The findings may improve perioperative management strategies for hypertensive patients receiving spinal anesthesia.
This study aims to investigate the relationship between carotid intima-media thickness (CIMT) and spinal anesthesia-induced hypotension (SASH) in hypertensive patients. SASH is a common side effect of spinal anesthesia, with an incidence ranging from 15% to 33%, and is associated with significant clinical consequences such as increased morbidity and mortality. CIMT is a well-established marker of atherosclerotic burden and cardiovascular risk. This study hypothesizes that CIMT may be an independent predictor of SASH in hypertensive patients. Participants will undergo preoperative CIMT measurements and standardized spinal anesthesia procedures, with hemodynamic variables and potential risk factors recorded for analysis.
1,003 studies on the registry are indexed under Hypotension; 173 are open to participants now.
This study's enrollment of 110 is above the median of 84 across 294 observational studies indexed under Hypotension.
Browse Hypotension studies →Konya City Hospital is the lead sponsor of 76 studies on the registry; 21 are open to participants now.
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The study will include adult hypertensive patients scheduled for elective surgical procedures under spinal anesthesia at Konya City Hospital. The target population comprises patients with hypertensive patients (ASA II-III classification), who are deemed fit for elective surgery and spinal anesthesia by their clinical teams.
Eligible participants will be screened based on inclusion and exclusion criteria. The study population represents a subset of hypertensive individuals with varying durations of hypertension, medication regimens, and cardiovascular profiles. Patients will be recruited from preoperative assessment clinics and surgical wards at the hospital.
Adult hypertensive patients classified as ASA II-III risk group. Patients scheduled for elective surgeries requiring spinal anesthesia.
Exclusion Criteria:
Presence of severe renal or hepatic failure, or severe respiratory or cardiovascular diseases.
Contraindication to spinal anesthesia. Failure of spinal anesthesia. History of carotid surgery or presence of carotid plaques. Presence of anxiety.
Incidence of Spinal Anesthesia-Induced Hypotension (SASH)
Percentage of patients experiencing a decrease in systolic blood pressure by 20% or more from baseline or a drop below 90 mmHg during the first 30 minutes following spinal anesthesia.
Time frame: 30 minutes after spinal anesthesia.
Predictive Value of Internal Jugular Vein Collapsibility Index
The collapsibility index of the inferior vena cava (IVC) will be measured using ultrasound. Measurements will be obtained during inspiration and expiration, and the collapsibility index will be calculated as \[(IVC diameter during expiration - IVC diameter during inspiration) / IVC diameter during expiration\] × 100%. Measurements will be performed preoperatively and 30 minutes after spinal anesthesia induction.
Time frame: Pre-anesthesia measurement.
Flow-Mediated Dilation (FMD)
FMD will be measured using high-resolution ultrasound to assess endothelial function. Measurements will be performed on the brachial artery at baseline and after inducing hyperemia with a blood pressure cuff. FMD will be calculated as \[(post-hyperemia diameter - baseline diameter) / baseline diameter\] × 100%. The average of three repeated measurements will be recorded for analysis.
Time frame: Pre-anesthesia measurement.
Carotid Corrected Flow Time (CFTc)
Carotid Corrected Flow Time (CFTc) will be measured using Doppler ultrasound at the common carotid artery. The uncorrected carotid flow time will be adjusted for heart rate using Bazett's formula (CFTc = observed flow time / √(R-R interval)). Measurements will be taken preoperatively and at 30 minutes after spinal anesthesia induction. The average of three consecutive measurements will be recorded.
Time frame: Pre-anesthesia measurement.
Plan to share: No
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This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
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Konya City Hospital