An observational study in Heavy Menstrual Bleeding and Bleeding Disorder, sponsored by University Hospital, Geneva. Recruiting at 1 site in Switzerland. Open to female participants aged Up to 25 Years. Per ClinicalTrials.gov, last updated 2026-05-12.
Sponsored by University Hospital, Geneva · Observational
The goal of this study is to evaluate whether hormonal medications (such as contraceptive pill, patch, injectable progestins and hormonal intra-uterine device) have similar efficacy at managing heavy menstrual bleeding in adolescents with a bleeding disorder compared to those without. We also aim to assess the quality of life and hemoglobin and iron levels in this population.
Adolescents with heavy menstrual bleeding and willing to start a hormonal medication to reduce menstrual flow are included. At baseline and during the study period, questionnaires and blood tests are performed. Adolescents with a bleeding disorder are compared to those without. Follow-up is 1 year.
206 studies on the registry are indexed under Menorrhagia; 35 are open to participants now.
This study's planned enrollment of 163 is below the median of 210 across 47 observational studies indexed under Menorrhagia.
Browse Menorrhagia studies →University Hospital, Geneva is the lead sponsor of 379 studies on the registry; 70 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adolescents and young adults presenting to the gynecology consultation at HUG.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Percentage of reduction in menstrual blood loss
Using PBAC (pictorial blood loss assessment chart)
Time frame: 6 months after hormonal medication initiation
Percentage of reduction in menstrual blood loss
Using PBAC
Time frame: 3 months following hormonal medication initiation
Percentage of reduction in menstrual blood loss
Using PBAC
Time frame: 12 months after hormonal medication initiation
Quality of life
QoL (measured by the Pediatric Quality of Life Inventory (PedsQL) for adolescents (13-18 years old) or young adults (19-25 years old)) ; range 0-100 with higher scores representing better quality of life.
Time frame: at baseline, 3 months, 6 months and 12 months
Hemoglobin and ferritin levels changes
Blood samples to measure hemoglobin and ferritin
Time frame: at baseline, 6 months and 12 months
Changes in thrombin generation markers
Blood sample
Time frame: at baseline and 6 months
Plan to share: Undecided
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