An observational study in Sepsis, sponsored by Menoufia University. Completed at 1 site in Egypt. Open to participants aged 19 Years to 75 Years. Per ClinicalTrials.gov, last updated 2024-12-06.
Sponsored by Menoufia University · Observational
Objectives: This study aims to determine the validity of hyperammonemia in predicting true sepsis compared to hyperlactemia in critically ill septic patients.
Background: Sepsis is associated with amino acid flux towards the liver, which increases the ammonia load. The combination of decreased clearance and increased load is thought to be the major cause of increased ammonia in sepsis.
Methodology: 60 septic patients were classified into 2 equal groups, Group I: Septic patients with positive microbial cultures. Group II: septic patients with negative cultures enrolled to obtain serum ammonia and lactic acid levels on admission and every six hours for three days. The primary outcome was to detect ammonia specificity and sensitivity in predicting sepsis in comparison to lactate. The secondary outcomes were need for mechanical ventilation, mortality, and length of stay (LHS) within the intensive care unit.
Objectives: The study compares between non-cirrhotic hyperammonemia and hyperlactemia in predicting sepsis in critically ill septic patients.
The septic patients were classified into 2 equal groups, Group I: Septic patients with positive microbial cultures. Group II: septic patients with negative cultures enrolled to obtain serum ammonia and lactic acid levels on admission and every six hours for three days, to detect ammonia specificity and sensitivity in predicting sepsis in comparison to lactate. also, need for mechanical ventilation, mortality, and length of stay (LHS) within the intensive care unit were reported.
1,946 studies on the registry are indexed under Sepsis; 471 are open to participants now.
This study's enrollment of 60 is below the median of 160 across 957 observational studies indexed under Sepsis.
Browse Sepsis studies →Menoufia University is the lead sponsor of 197 studies on the registry; 53 are open to participants now.
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patient with sepsis or septic shock
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Exclusion Criteria:
Serum ammonia specificity and sensitivity in predicting sepsis in comparison to lactate
Blood samples to obtain Serial ammonia and lactic acid levels
Time frame: up to three days.
Plan to share: No — it needs patient and institutional ethical committee approval
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This study is completed, as verified in Dec 2024. You cannot join it, but the record below documents what was studied.
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