An interventional study of Neuromuscular Exercise Training and Conventional Exercise Training in Multiple Sclerosis, sponsored by Istanbul Aydın University. Not yet recruiting. Open to participants aged 18 Years to 64 Years. Per ClinicalTrials.gov, last updated 2024-12-04.
Sponsored by Istanbul Aydın University · Not applicable, Interventional, and Treatment
The effectiveness of upper extremity focused neuromuscular exercise training in early stage people with MS will be investigated. People with MS enrolled in the study will be randomly assigned to three groups: Neuromuscular Exercise Group (NEG), Conventional Exercise Group (CEG), and Control Group (CG). All three groups will be assessed with primary and secondary outcome measures at baseline, week 8, and week 12. NEG, CEG, and CG will be initially assessed for upper extremity function, cognitive function, lower extremity function, grip strength, proximal muscle strength, sensation, coordination, fatigue, postural sway, and core muscle strength and endurance. Then, NEG will receive clinically supervised upper extremity focused neuromuscular exercise training with a minimum of 60 minutes of session time, 2 days a week for 8 weeks. This exercise training includes steps for postural control, weight transfer, proximal and distal muscle strengthening, proprioception, coordination and reaction speed. Similarly, CEG will receive clinically supervised traditional upper extremity exercise training, twice a week for 8 weeks, with a minimum of 60 minutes of session time. This exercise training includes strengthening with the band and manuel dexterity exercises. In both groups, stretching and mobility exercises will be added to the warm-up and cool-down exercises before and after the program. During this process, CG will be on the waiting list. At the end of 8 weeks, all three groups will be re-evaluated. After the exercise training, follow-up will be done and evaluations will be repeated in the 12th week. This study will provide evidence on the effects of upper extremity-focused neuromuscular exercise training on physical and cognitive functions in early-stage people with MS compared to traditional treatment approaches.
3,524 studies on the registry are indexed under Multiple Sclerosis; 668 are open to participants now.
This study's planned enrollment of 72 is above the median of 50 across 2,386 interventional studies indexed under Multiple Sclerosis.
Browse Multiple Sclerosis studies →Istanbul Aydın University is the lead sponsor of 70 studies on the registry; 20 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Upper Extremity Focused Neuromuscular Exercise Training
Other: Neuromuscular Exercise Training
Traditional Upper Extremity Exercise Training
Other: Conventional Exercise Training
Control Group
This group will receive neuromuscular exercise training with 60-75 minute sessions per day, 2 days a week, for 8 weeks. Warm-up Program - 5 minutes Postural Control-Weight Transfer - 10-15 minutes Strength Training - 30-35 minutes Proprioception - Coordination - Reaction Speed 10-15 minutes Cool-down Program - 5 minutes
This group will be given traditional strength exercise training consisting of 60-75 minute sessions per day, 2 days per week for 8 weeks. Warm-up Program - 5 minutes Strength Training - 30-35 minutes Manuel Dexterity - 15-20 minutes Cool-down Program - 5 minutes
Nine Hole Peg Test
To assess unilateral function of the upper extremity
Time frame: At the beginning, at the end of 8 weeks and 12 weeks
Minnesota Manual Dexterity Test
To assess bilateral upper extremity function
Time frame: At the beginning, at the end of 8 weeks and 12 weeks
Manual Ability Measure-36
To assess upper extremity function. A higher score indicates better hand function.
Time frame: At the beginning, at the end of 8 weeks and 12 weeks
Timed 25-Foot Walk
To assess lower extremity function
Time frame: At the beginning, at the end of 8 weeks and 12 weeks
Symbol Digit Modalities Test
To assess cognitive function
Time frame: At the beginning, at the end of 8 weeks and 12 weeks
Hand Dynamometer
To assess hand grip strength
Time frame: At the beginning, at the end of 8 weeks and 12 weeks
Hand Held Dynamometer
To assess elbow muscle strength
Time frame: At the beginning, at the end of 8 weeks and 12 weeks
Biodex Balance System
To assess postural sway
Time frame: At the beginning, at the end of 8 weeks and 12 weeks
Laser-pointer Assisted Angle Reproduction Test
To assess of shoulder proprioception
Time frame: At the beginning, at the end of 8 weeks and 12 weeks
Finger Tapping Test
To assess upper extremity coordination
Time frame: At the beginning, at the end of 8 weeks and 12 weeks
Fatigue Severity Scale
To assess fatigue severity. A high score indicates high fatigue severity.
Time frame: At the beginning, at the end of 8 weeks and 12 weeks
Plank
To assess core muscle endurance
Time frame: At the beginning, at the end of 8 weeks and 12 weeks
Curl-up
To assess core muscle strength
Time frame: At the beginning, at the end of 8 weeks and 12 weeks
No study locations are listed for this record.
This study is not yet recruiting, as verified in Dec 2024. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Istanbul Aydın University