An interventional study of Group acceptance and commitment therapy (ACT) and Treatment as usual in Major Depressive Disorder (MDD), sponsored by Universiti Sains Malaysia. Completed at 1 site in Malaysia. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-11-29.
Sponsored by Universiti Sains Malaysia · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to learn if group acceptance and commitment therapy works to improve depressive symptoms, psychological flexibility and quality of life in adults. The main questions it aims to answer are:
Researchers will compare group ACT group to a treatment-as-usual (TAU) group to see if group ACT works to improve depressive symptoms, quality of life and psychological flexibility.
Participants will:
General Objectives To study the effectiveness of group Acceptance and Commitment Therapy in the treatment of depression among depressive patients in Kelantan.
Specific Objectives
This quasi-experimental study used a two-group design, comparing group ACT with TAU at baseline, post-intervention, and a 3-month follow-up. Conducted at the Psychiatry Clinic, Hospital Universiti Sains Malaysia, from June 2022 to May 2024, the study included 44 participants with mild to moderate depression. Twenty-two participants allocated in the ACT group received weekly group ACT sessions over four weeks, while twenty-two participants were assigned to the TAU group. Outcomes were measured using the Malay versions of the Beck Depression Inventory I (BDI), WHO Quality of Life-BREF (WHOQOL-BREF), and Acceptance and Action Questionnaire II (AAQ-II) at baseline, post-intervention, and at 3-month follow-up. Data was analyzed using two-way Repeated Measures Analysis of Variance (RM ANOVA) to assess changes in these outcomes across the different time points.
4,845 studies on the registry are indexed under Depressive Disorder; 514 are open to participants now.
This study's enrollment of 44 is below the median of 80 across 3,999 interventional studies indexed under Depressive Disorder.
Browse Depressive Disorder studies →Universiti Sains Malaysia is the lead sponsor of 171 studies on the registry; 48 are open to participants now.
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Exclusion Criteria:
Participants of this arm underwent 4 weeks of weekly session of acceptance and commitment therapy (ACT).
Behavioral: Group acceptance and commitment therapy (ACT)
The participants in this group received standard treatment for major depressive disorder
Other: Treatment as usual
The ACT intervention module utilized in this study was adapted from Hayes foundational work on ACT and Harris. A summary of the general contents and exercises in each week was in accordance with the 6 core processes of Acceptance and Commitment Therapy based on Hayes. It was conducted in the Malay language. The same workbook with guided exercise and homework were used by all the therapists to assure standardization of the intervention to ensure that each group received similar contents in each session.
Standard care and follow-up for major depressive disorder
Depressive symptoms
The outcome was measured by using Beck Depression Inventory (BDI)
Time frame: From enrollment to the end of treatment at 4 weeks
Quality of life
The outcome was measured by using brief WHO Quality of Life (WHOQOL) questionnaire (Malay version)
Time frame: From enrollment to the end of treatment at 4 weeks
Psychological flexibility
The outcome was measured using Acceptance and Action Questionnaire II Malay Version (AAQ-II)
Time frame: From enrollment to the end of treatment at 4 weeks
Depressive symptoms (3 months)
It was measured using BDI at 3 months post-intervention
Time frame: 3 months post intervention
Quality of life (3 months)
It was measured using WHOQOL at 3 months post-intervention
Time frame: 3 months post intervention
Psychological flexibility (3 months)
It was measured using AAQ-II at 3 months post-intervention
Time frame: 3 months post intervention
Plan to share: No
This study is completed, as verified in Nov 2024. You cannot join it, but the record below documents what was studied.
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Universiti Sains Malaysia